Synthesis and Characterization of Air‐Stable Palladium(II) and Copper(I) Ph‐Garphos Complexes and their Applications to Asymmetric Catalysis
Bibliographic record
Abstract
Abstract Air‐stable palladium(II) and copper(I) complexes containing the 4,4′,6,6′‐tetramethoxybiphenyl‐2,2′‐diyl)bis(diphenylphosphine) ligands, ( R )‐Ph‐Garphos (( R )‐ L1 ) and (( S )‐Ph‐Garphos (( S )‐ L1 ), were synthesized and characterized by 1 H‐, 13 C‐, and 31 P{ 1 H} NMR spectroscopy and elemental analyses. The PdCl 2 (( R )‐Ph‐Garphos) (( R )‐ 1 ) and PdCl 2 (( S )‐Ph‐Garphos) (( S )‐ 1 ) complexes were assessed for the Suzuki‐Miyaura cross‐coupling of aryl halides with phenylboronic acid under ambient conditions, or naphthyl substrates under reflux. X‐ray crystal structures of the copper complexes revealed that [Cu(( R )‐Ph‐Garphos)I] (( R )‐ 2 ) crystallized as a three‐coordinate monomer in the orthorhombic space group P 2 1 2 1 2 1 whereas [Cu(( S )‐Ph‐Garphos)I] (( S )‐ 2 ) crystallized as a tetrahedral (μ‐I) dimer in the same crystal system. The synthesis of the analogous [Cu(( R )‐Ph‐Garphos)OAc] (( R )‐ 3 ) is also described. Complexes ( R )‐ 2 and ( R )‐ 3 were evaluated for the asymmetric hydrosilylation of ketones wherein enantioselectivities of up to 83 % ee were achieved.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".