A-335 Evaluation of the Next Generation <i>i-STAT</i>® Point of Care Prothrombin Time Test
Bibliographic record
Abstract
Abstract Background The i-STAT® PTplus cartridge contains a point of care prothrombin time (PT) test. The purpose of this study was to assess the performance of the i-STAT PTplus cartridge compared to other commercially available PT tests namely, Dade® Innovin® on the Sysmex® CS-2500 and the Roche CoaguChek®. The i-STAT® PTplus cartridge is a point of care whole blood test for the determination of prothrombin time. It is used to aid in the monitoring of patients receiving anticoagulant therapy with coumarin derivatives. Methods Venous and capillary whole blood specimens were prospectively collected with IRB approved informed consent from 222 subjects undergoing coumarin therapy and from subjects who were not on anticoagulant therapy at three clinical sites to span the reportable range of 0.8 - 8.0 INR. Both venous and capillary whole blood specimens were tested in duplicate on the i-STAT 1 Wireless Analyzer and were tested in singlicate on the Roche CoaguChek® device. Plasma from a citrated venous blood specimen obtained from the same subjects was tested in duplicate on the Sysmex® CS-2500 instrument. Results The Passing-Bablok regression results in the table below demonstrate international normalized ratio (INR) in the first replicate of the i-STAT PTplus cartridge versus the first replicate comparative device for venous and capillary whole blood. Conclusions This study demonstrates that the i-STAT® PTplus cartridge has good agreement to both laboratory and point of care commercially available PT tests when tested with venous and capillary whole blood from subjects not on anticoagulant therapy and subjects receiving coumarin therapy. The studies were funded by Abbott Laboratories.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".