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Record W4403164491 · doi:10.1101/2024.10.05.24314949

A playbook for harmonization of standards for emergent viral pathogens

2024· preprint· en· W4403164491 on OpenAlexaff
Sara Suliman, Sébastien Fuchs, David Catoe, Loren Hansen, Deepa Eveleigh, Michael A. Crone, Paul S. Freemont, Martin Kammel, Heinz Zeichhardt, Andrew Anfora, Russell Garlick, Neil Almond, Mark Page, Brian J. Beck, Hui Wang, Karuna Sharma, Gary A. Pestano, Joannes Vancann, Jo Vandesompele, Adam S Corner, Jeffrey H. Albrecht, Deborah Boles, Marcia Eisenberg, Ayla B. Harris, Brian J. Krueger, Amanda L. Suchanek, Thomas Urban, Jonathan Williams, Patrick Chain, Alina Deshpande, Attelia Hollander, Sujata Chalise, David R. Walt, Jeffrey J. Germer, Joseph D. Yao, Bobbi S. Pritt, Frederick S. Nolte, Alexandra Bogožalec Košir, Mojca Milavec, Megan H. Cleveland, Peter M. Vallone, Eloise J. Busby, Jim F. Huggett, Denise M. O’Sullivan, Elizabeth M. Marlowe, Benjamin A. Pinsky, Annaleise Kealiher, Jeantine E. Lunshof, Christopher E. Mason, John J. Sninsky, Cristina M. Tato, Tim R. Mercer, Thomas J. White, Marc Salit

Bibliographic record

VenuemedRxiv · 2024
Typepreprint
Languageen
FieldMedicine
TopicZoonotic diseases and public health
Canadian institutionsCanadian Society of MicrobiologistsWestern University
Fundersnot available
KeywordsHarmonizationVirologyBusinessBiologyPhilosophy

Abstract

fetched live from OpenAlex

Abstract Effective clinical and public health decision-making during a pandemic depends on reliable and interoperable clinical diagnostic test results. To ensure trustworthy outcomes, we need widely available and harmonized calibration standards on a shared scale. We present a ‘playbook’ for an inter-laboratory harmonization study that calibrates any available standards against a limited-availability standard issued by a global authority like the World Health Organization (WHO).

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.040
metaresearch head score (Gemma)0.062
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: Methods · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.960
Threshold uncertainty score0.296

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0400.062
Meta-epidemiology (narrow)0.0030.002
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0050.003
Science and technology studies0.0020.002
Scholarly communication0.0060.008
Open science0.0050.009
Research integrity0.0040.005
Insufficient payload (model declined to judge)0.0880.036

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.036
GPT teacher head0.356
Teacher spread0.321 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designTheoretical or conceptual
DomainMethods
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes1
Has abstractyes

Explore more

Same venuemedRxiv→Same topicZoonotic diseases and public health→French-language works237,207→