Synthesis of α-Quaternary Aldehydes via a Dual Ni/Rh-Catalyzed Tandem Isomerization–Propargylation Reaction
Bibliographic record
Abstract
A dual Ni/Rh catalysis sequence toward α-quaternary aldehydes is reported. An intramolecular approach from allyl propargyl carbonates alongside the intermolecular transformation from allylic alcohols and propargyl carbonates is described. Initial decarboxylative oxidative addition into the propargyl group by nickel generates the electrophilic Ni–allenyl species, and the resulting allylic alkoxide is isomerized into the nucleophilic Rh–enolate species. Upon recombination, the α-propargylated aldehyde is obtained. Preliminary enantioselective results are reported, with varying protocols using either a dual metal single ligand or a dual metal dual ligand system.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".