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An infrastructure for qualified data sharing and team science in late-stage translational spinal cord injury research

2024· review· en· W4403312288 on OpenAlexaff
J. Russell Huie, Abel Torres‐Espín, Jeffrey Sacramento, Anastasia Keller, Wilsaan M. Joiner, Ryan North, David J. Reinkensmeyer, E Rosenzweig, Jacob Koffler, Mark H. Tuszynski, Carolyn J. Sparrey, Jessica L. Nielson, Michael S. Beattie, Jacqueline C. Bresnahan, Jeffrey S. Grethe, Adam R. Ferguson

Bibliographic record

VenueExperimental Neurology · 2024
Typereview
Languageen
FieldMedicine
TopicHealth and Medical Research Impacts
Canadian institutionsSimon Fraser UniversityUniversity of Alberta
FundersNational Institutes of HealthNational Institute of Arthritis and Musculoskeletal and Skin DiseasesBernard and Anne Spitzer FoundationNational Center for Research ResourcesNational Institute of Neurological Disorders and StrokeBernard and Anne Spitzer Charitable TrustCraig H. Neilsen FoundationWings for LifeDr. Miriam and Sheldon G. Adelson Medical Research FoundationU.S. Department of Veterans Affairs
KeywordsTranslational researchSpinal cord injuryStage (stratigraphy)Spinal cordData sharingNeurosciencePsychologyMedicineBusinessPhysical medicine and rehabilitationBiologyAlternative medicine

Abstract

fetched live from OpenAlex

The complex and heterogeneous nature of spinal cord injury has limited translational bench-to-bedside results. The wide variety of data, including injury parameters, biochemical, histological, and behavioral outcome measures represent a ‘big data’ problem, calling for modern data science solutions. There are some instances in which SCI researchers collect sensitive data that needs to remain private, such as datasets designed to meet regulatory approval, sensitive intellectual property, and non-human primate studies. For these types of data, we have developed a Private Data Commons for SCI (PDC-SCI). Our objective is to give an overview of this novel data commons, describing how this type of commons works, how it can benefit the research community, and the cases in which it would be most useful. This private infrastructure is ideal for multi-lab transdisciplinary studies that require a well-organized, scalable data commons for rapid data sharing within a closed, distributed team. As a use-case for the PDC-SCI, we demonstrate the VA Gordon Mansfield SCI Consortium, in which multimodal data from behavior, biomechanics of injury, hospital records, imaging, and histology are integrated, shared, and analyzed to facilitate insights and knowledge discovery. • Private data commons (PDC) allows researchers in team science to share sensitive data securely among themselves. • Ideal for multilab transdisciplinary studies that require a well-organized, scalable data commons. • The PDC facilitates the integration, sharing, and analysis of multimodal data for knowledge discovery.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.005
metaresearch head score (Gemma)0.004
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesResearch integrity
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.980
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0050.004
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0000.002
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.535
GPT teacher head0.644
Teacher spread0.109 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes1
Has abstractyes

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