Antimicrobial Activity of Compounds Isolated from Uvaria wrayi (King) L.L. Zhou, Y.C.F. Su & R.M.K. Saunders Leaves and Twigs
Bibliographic record
Abstract
Antimicrobial resistance (AMR) refers to the capacity of bacteria to resist the impact of antibiotics, emerging as a significant global health concern. To discover novel antibacterial agents, the isolation and elucidation of compounds from leaf and twig extracts of Uvaria wrayi (King) L.L. Zhou, Y.C.F. Su & R.M.K. Saunders were investigated for the first time. 9 known compounds were performed and categorized as polyoxygenated cyclohexenes (1-3), seco-cyclohexenes (4), acrylamide derivatives (5,6), and aristolactam alkaloids (7-9). All isolated compounds were evaluated for their antimicrobial activities against 5 Gram-positive bacteria, including Staphylococcus aureus (TISTR 746), Staphylococcus epidermidis (DMST 15505), Methicillin-resistant Staphylococcus aureus (MRSA) (NPRC 001R), Cutibacterium acnes (formerly Propionibacterium acnes) (DMST 14916), and Streptococcus mutans (DMST 18777/ATCC 25175T). 2 Gram-negative bacteria, Shigella flexneri (DMST 4423) and Salmonella enterica ser. typhimurium (TISTR 2519) were evaluated. Most of the isolated compounds displayed moderate antimicrobial activity with a MIC value of 64 µg/mL, except compounds 1,9 showed antibacterial against MRSA with a MIC value of 128 µg/mL. Compounds 2-9 exhibited antimicrobial activity against C. acnes (DMST 14916) with a MIC value of 32 µg/mL. Compounds 1-3, 6, and 7 also responded to inhibit C. acnes with the same MBC value of 128 µg/mL. This exploration holds promise for advancing our understanding of potential antibacterial compounds within U. wrayi and addressing the challenges posed by antimicrobial resistance. HIGHLIGHTS The first phytochemical investigation of U. wrayi resulted in the isolation and identification of nine antibactiral compounds. Compounds 2-9 exhibited antimicrobial activity against Cutibacterium acnes (DMST 14916) with a MIC value of 32 µg/mL. Most of the isolated compounds displayed moderate antimicrobial activity with a MIC value of 64 µg/mL. GRAPHICAL ABSTRACT
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".