Patterns of progression in a contemporary cohort of 447 patients with smoldering multiple myeloma
Bibliographic record
Abstract
Smoldering multiple myeloma (SMM) is considered an asymptomatic plasma cell disorder preceding multiple myeloma (MM). The course of SMM disease is heterogenous, largely driven by disease biology and tumor burden [ 1 , 2 ]. Routine clinical surveillance or early treatment, mostly within clinical trials, is thus based on the likelihood of developing a myeloma defining event (MDE) requiring systemic treatment [ 3 ]. Current stratification models for risk of progression include bone marrow plasma cell (BMPC) infiltration, monoclonal (M) protein component, ratio of involved/uninvolved serum free light chains (FLCr), and cytogenetic abnormalities [ 4 , 5 ]. Early systemic treatment of high-risk SMM has shown to improve progression free survival in two trials and overall survival (OS) in one of them [ 6 , 7 ]. However, early treatment of SMM is not considered a standard of care [ 8 , 9 ].
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".