S1085 The Hidden Burden of Fatigue in Moderate-to-Severe Crohn’s Disease and Ulcerative Colitis: Results From the Communicating Needs and Features of IBD Experiences (CONFIDE) Survey
Bibliographic record
Abstract
Introduction: The Communicating Needs and Features of Inflammatory bowel disease (IBD) Experiences (CONFIDE) study explored experiences and impact of Crohn’s disease (CD)/Ulcerative colitis (UC)-related symptoms in Europe (EU5: France, Germany, Italy, Spain, and UK), the United States (US) and Japan. These analyses focus on EU5 and US patients (pts). Methods: Online, quantitative, cross-sectional surveys were conducted among pts with moderate-to-severe CD/UC, defined by previous treatment, steroid use, and/or hospitalization. Fatigue over past 7 days was assessed using Functional Assessment of Chronic Illness Therapy–Fatigue (FACIT–F) scale (range: 0–52). Manitoba IBD Index assessed pt-reported disease activity in last 6 months (6-level scale); disease was considered active if constantly-to-occasionally experienced symptoms (responses 1–4), and inactive if infrequent/absent (responses 5/6). Pt-reported impact of CD/UC on energy levels was reported on a scale of 1 (no impact)–7 (high impact). Results: Total 547 EU5 (55.4% male, mean age: 38.0 years) and 215 US (54.9% male, 40.9 years) pts with CD and 556 EU5 (57.4% male, 38.9 years) and 200 US (61.5% male, 40.4 years) pts with UC completed the surveys. Overall, 34.2% EU5 and 35.8% US pts with CD, and 20.9% EU5 and 27.5% US pts with UC reported currently (in the last month) experiencing fatigue; overall >80% indicated that CD/UC negatively impacted their energy levels: CD, EU5: 80.1%, US: 84.2%; UC, EU5: 81.1%, US: 88.0%. Mean±SD FACIT-F scores: 27.4±11.3 and 26.8±10.8 for EU5 and US pts with CD, and 29.4±10.0 and 26.2±11.3 for EU5 and US pts with UC, respectively. FACIT-F scores among pts currently experiencing fatigue: 24.3±10.8 and 26.1±10.9 for EU5 and US pts with CD, and 26.0±10.6 and 24.5±11.5 for EU5 and US pts with UC. Of those currently experiencing fatigue, most pts with CD reported active disease (CD, EU5: 92.5%, US: 93.5%; UC, EU5: 92.2%, US: 98.1%). Among pts reporting ever experiencing fatigue (CD, EU5: 45.2%, US: 45.6%; UC, EU5: 30.6%, US: 40.0%), most reported experiencing fatigue at least once a week (CD, EU5: 67.5%, US: 79.6%; UC, EU5: 66.4%, US: 70.0%). Conclusion: EU5 and US pts with CD/UC reported severe fatigue (FACIT-F scores < 30), indicating major fatigue burden, which is clearly associated with pt-reported active disease. Both CD and UC negatively impact energy levels for most pts. The findings underscore the value of active fatigue management in CD/UC to improve pts’ quality of life.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".