PP380 Topic: AS13–Hematology/Oncology/Stem Cell Transplant/Immunology: CANADIAN NATIONAL SURVEILLANCE OF PEDIATRIC PULMONARY THROMBOEMBOLISM: A COMPARISON OF CHILDREN WHO WERE AND WERE NOT ADMITTED TO THE PEDIATRIC INTENSIVE CARE UNIT
Bibliographic record
Abstract
Aims & Objectives: Pediatric pulmonary thromboembolism (PE) is a rare but potentially life-threatening event. This study compares risk factors, symptoms, diagnostic modalities, interventions, and short-term outcomes for children with PE who were and were not managed in PICU. Methods: Between January 2020 and December 2022, monthly surveillance was conducted with over 2,800 pediatricians and sub-specialists in Canada. Voluntary reporting of cases was followed up with a detailed questionnaire. Results: Detailed information was available for 31 (53%) of 58 reported cases; 11 (35%) were managed in PICU. PICU patients were of similar age (median 15.8 years; interquartile range 8.8-16.6 years) to non-PICU patients (median 15.6 years; interquartile range 13.3-16.9 years), p=0.52. No significant differences were observed between proportions of PICU and non-PICU patients who were female (82% vs 80%, p=0.9), symptomatic (82% vs 90%, p=0.52), had at least one risk factor (91% vs 90%, p=0.93), presented to non-tertiary hospitals (55% vs 60%, p=0.77), and diagnosed using computed tomography pulmonary angiography (64% vs 90%, p=0.07). PICU patients were more often initially treated with unfractionated heparin (n=6; 55%) compared to non-PICU patients, who received low molecular weight heparin (n=17; 85%), p<0.01. PICU patients experienced major complications of treatment (n=5; 45%), whereas fewer than 5 non-PICU patients had only minor complications, p=0.06. All reported mortalities (<5) occurred in PICU patients. Conclusions: Initial therapy differed between children with PE who were and were not admitted to PICU. Whether this can be accounted for by severity of illness upon presentation or treatment complications is unclear. Keywords: hematology, venous thromboembolism, pulmonary embolism
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.003 | 0.005 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.017 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".