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Record W4404091409 · doi:10.1093/pch/pxae078

Supporting adolescents presenting with illicit drug toxicity

2024· article· en· W4404091409 on OpenAlexaff
Matthew Carwana, Eva Moore, Nicholas Chadi

Bibliographic record

VenuePaediatrics & Child Health · 2024
Typearticle
Languageen
FieldMedicine
TopicOpioid Use Disorder Treatment
Canadian institutionsCentre Hospitalier Universitaire Sainte-JustineUniversité de MontréalLearning PartnershipBC Children's HospitalUniversity of British Columbia
Fundersnot available
KeywordsIllicit drugDrugToxicityMedicinePharmacologyInternal medicine

Abstract

fetched live from OpenAlex

A 16-year-old male-identifying young person is brought into the emergency department (ED) by emergency health services (EHS) who were called due to the teen having an unresponsive episode during an evening out with friends. He had taken a pill that he believed to be MDMA, and lost consciousness approximately 5 min after ingestion. His friend administered one dose of intranasal naloxone (4 mg), which had a partial effect, but the patient remained obtunded. EHS provided an additional dose of naloxone (0.4 mg given intramuscularly) during transport, with minimal improvement in the level of consciousness. Upon arrival at the ED, the patient is minimally responsive and has a Glasgow Coma Scale (GCS) score of 9 (eyes 2, motor 5, and verbal 2). His heart rate is 78 beats/min, blood pressure is 104/68 mm Hg, respiratory rate is 10 breaths/min, oxygen saturation is 94% on 6 L of oxygen provided via a non-rebreather mask, and temperature is 36.1°C (axillary). An additional dose of intramuscular naloxone 0.4 mg is administered with minimal effect. Further investigations show a normal hematology panel and normal electrolytes. Capillary blood gas shows mild respiratory acidosis with a pH of 7.29, pCO2 of 54, and HCO3 of 24. A urine toxicology screen is positive for cannabinoids, MDMA, fentanyl, and benzodiazepines. Given the presence of benzodiazepines, reversal with flumazenil is considered, but not administered, as the patient’s GCS score and respiratory rate are steadily improving. He is managed with supportive care until his GCS score returns to 15.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.008
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Commentary · Consensus signal: none
Teacher disagreement score0.013
Threshold uncertainty score0.042

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.008
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0020.000
Scholarly communication0.0010.001
Open science0.0010.002
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.0130.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.299
Teacher spread0.289 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes1
Has abstractno

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