Variability of lung function tests in primary ciliary dyskinesia
Bibliographic record
Abstract
Introduction: While variability of forced expiratory volume in one second (FEV1) has been previously assessed in cystic fibrosis (CF), there is a lack of evidence in primary ciliary dyskinesia (PCD) on intra-individual variability during routine clinic visits. Methods: This is a retrospective study of children ages 6-18 years with a confirmed diagnosis of PCD followed between 2000-2022. Only visits where patients were considered clinically stable were included in the analysis. A mixed effects model was generated with age as the time variable, random intercepts per individual, with pre bronchodilator FEV1 percent predicted (FEV1pp) and Z-scores as the outcomes. Results: Among the 103 children included, the median follow up period was 4.8 years (IQR 2.7, 8.2) and the median time between included visits was 126 days (91, 210) (Figure 1). The median number of measurements per child was 9 (IQR 5, 18). The intra class correlation between stable visits was 0.78 (95% CI 0.73, 0.83) and 0.79 (95% CI 0.73, 0.83) in FEV1z and FEV1pp, respectively with 95% of the absolute differences between measurements expected to be less than 1.17 z-score (CR=1.17) and 14% predicted (CR=14). In this dataset, 281/1135 (25%) of the measurements changed by >10% predicted from the last visit. Conclusion: PCD patients considered to be clinically stable, have large intra individual variability between routine clinic visits, similar to what has been previously reported in CF. erj;64/suppl_68/PA3315/F1 F1 F1
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.012 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".