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Evaluation of waning of IgG antibody responses after rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo Ebola virus disease vaccines: a modelling study from the PREVAC randomized trial
Simon Valayer, Marie Alexandre, Mélanie Prague, Abdoul Habib Béavogui, Seydou Doumbia, Mark Kieh, Brian Greenwood, Bailah Leigh, Marie Poupelin, Christine Schwimmer, Samba O. Sow, Irina Maljkovic Berry, Jens H. Kuhn, Natasha Dubois Cauwelaert, Deborah Watson-Jones, Rodolphe Thiébaut, Yves Lévy, Yazdan Yazdanpanah, Laura Richert, Edouard Lhomme, Jamila Aboulhab, Michelle Aguirre-MacKenzie, Pauline Akoo, Esther Akpa, Robert Akpata, Sara Albert, Boni Maxime Ale, Serry Alimamy-Bangura, Pierre Andong, Benetta C. Andrews, Stephane Anoma, Negin Atri, Augustin Augier, Ken Awuondo, Ahidjo Ayouba, Moses Badio, Aminata Bagayoko, Abby Balde, Joséphine Balssa, Lamin Molecule Bangura, Kesha Barrington, Eric Barte de Saint Fare, Beth Baseler, Ali Bauder, Claire Bauduin, Luke Bawo, Michael Belson, Safaa Ben-Farhat, Marion Bererd, Nicolas Bernaud, Teedoh Beyslow, Jeanne Billioux, Shere Billouin-Frazier, Blandine Binachon, Julie Blie, Viki Bockstal, Patricia Boison, Fatorma K. 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Bibliographic record
VenueEmerging Microbes & Infections · 2024
Typearticle
Languageen
FieldMedicine
TopicViral Infections and Outbreaks Research
Canadian institutionsUniversité de Montréal
FundersEuropean and Developing Countries Clinical Trials PartnershipJanssen Alzheimer Immunotherapy Research And DevelopmentJanssen BiotechInnovative Medicines InitiativeUniversité de BordeauxMinistère de l'Enseignement Supérieur et de la RechercheCenter for Biomedical Informatics and Information Technology, National Cancer InstituteEuropean CommissionFrederick National Laboratory for Cancer ResearchInstitut National de la Santé et de la Recherche MédicaleBavarian NordicMerck Sharp and DohmeCentre National de la Recherche ScientifiqueNational Cancer InstituteEuropean Federation of Pharmaceutical Industries and AssociationsNational Institutes of HealthNational Institute of Allergy and Infectious DiseasesHorizon 2020London School of Hygiene and Tropical Medicine
KeywordsEbola vaccineMedicineVirologyEbola virusAntibodyAntibody responseDiseaseImmunologyEbolavirusVirusInternal medicine
Abstract
OpenAlex records an abstract for this work, but it could not be fetched just now.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.314
Threshold uncertainty score0.789
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.042
GPT teacher head0.387
Teacher spread0.345 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations4
Published2024
Admission routes1
Has abstractyes