Methicillin-resistant and methicillin-susceptible Staphylococcus aureus in French hedgehogs admitted to a wildlife health center
Why this work is in the frame
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Bibliographic record
Abstract
The mecC gene conferring methicillin-resistance has always been found on a SCC mec type XI element and is largely restricted to the few clonal complexes CC130, CC1943, CC425, CC49 and CC599. The occurrence of the mecC gene in many different hosts highlighted its One Health importance, even though European hedgehogs ( Erinaceus europaeus ) are considered its natural reservoir, most probably because of the selective pressure imposed by beta-lactam-producing dermatophytes ( Trichophyton erinacei ) that colonize the skin of these mammals. Surprisingly, while the presence of T. erinacei on the French territory has been proven, no mecC -positive methicillin-resistant Staphylococcus aureus (MRSA) isolate has been reported yet from hedgehogs. We thus sampled 139 hedgehogs brought to a wildlife center; 128 were S. aureus carriers and 25 (18.0 %) presented a MRSA isolate, of which 21 (15.1 %) displayed the mecC gene. All 161 S. aureus collected were whole-genome sequenced. The mecC -MRSA belonged to the classical CCs, i.e. CC130, CC1943 and CC49. The majority (98/139, 70.5 %) of the methicillin-susceptible Staphylococcus aureus (MSSA) isolates also belonged to these three CCs. A phylogenetic comparison with mecC -MRSA isolates from all over Europe and New-Zealand showed local adaptations, despite the fact that they all belonged to the same CCs. The acquisition of the SCC mec type XI element by a concomitant MSSA could not be observed in the same animal, but such a transfer might be suggested since identical clones were identified, one MSSA and one MRSA, though in different animals. In parallel, we conducted a detailed analysis of the SCC mec type XI element as well as specific virulence factors (a tst variant and the vwb SaPI gene). Results led us to hypothesize that the mecC gene might be acquired through selective pressure of T. erinacei on MSSA, some of which were acquired a long time ago from ruminants and are now colonizing the skin of the hedgehogs. • 18.0 % (25/139) of the hedgehogs presented at least one MRSA. • Four animals were mecA -MRSA carriers, 21 were mecC -MRSA carriers. • mecC -MRSA belonged to CC130/ST130, CC1943 (ST1943 and ST2361) and CC49/ST6834. • 98/139 (70.5 %) MSSA isolates also belonged to CC130, CC1943 and CC49. • The sec , sel and tst genes were observed in 8 MRSA CC1943 and 22 MSSA isolates.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it