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Record W4404816742 · doi:10.7554/elife.97827.3.sa0

eLife Assessment: CPT1A mediates radiation sensitivity in colorectal cancer

2024· peer-review· en· W4404816742 on OpenAlexaff
Norma Ybarra

Bibliographic record

Venuenot available
Typepeer-review
Languageen
FieldMedicine
TopicRadiomics and Machine Learning in Medical Imaging
Canadian institutionsMcGill University Health Centre
Fundersnot available
KeywordsColorectal cancerSensitivity (control systems)Radiation sensitivityOncologyInternal medicineCancerMedicinePhysicsEngineeringIrradiationNuclear physics

Abstract

fetched live from OpenAlex

CPT1A downregulation enhances radioresistance in colorectal cancer (CRC) via FOXM1-mediated antioxidant response, making it a potential biomarker for radiosensitivity and a novel target for improving CRC radiotherapy.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.006
metaresearch head score (Gemma)0.021
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: Evaluation · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Commentary · Consensus signal: none
Teacher disagreement score0.994
Threshold uncertainty score0.177

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0060.021
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0020.001
Science and technology studies0.0010.001
Scholarly communication0.0030.002
Open science0.0010.002
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0530.017

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.015
GPT teacher head0.377
Teacher spread0.362 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
DomainEvaluation
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes1
Has abstractyes

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