Elimination Diet Guided by Food-Specific IgG Antibodies Measurements in Chronic Adult Acne in Thailand: A Prospective RCT Study
Bibliographic record
Abstract
Background: Adult female acne is increasingly prevalent and significantly affects quality of life. Current treatments, including antibiotics and hormonal therapies, often yield varied efficacy and risks. While adult acne shares similarities with adolescent acne, its pathogenesis involves genetic, hormonal, immune, and dietary factors. Emerging research implicates high glycemic load diets, milk proteins, and insulin/IGF1 signaling in exacerbating acne. Despite growing understanding, dietary influences remain poorly understood, overshadowed by persistent myths. Inflammation, preceding follicular plugging and hyperkeratinization, suggests a potential shift towards addressing gut inflammation and digestive issues. IgG-mediated food reactions, linked to conditions like IBS and migraines, are controversial in diagnosing acne but warrant investigation, especially in Thai patients. Objective: Evaluate the efficacy of elimination diets guided by food-specific IgG antibodies measurement in chronic adult acne. Patients and Methods: This randomized controlled trial and prospective cohort study enrolled 75 participants with chronic acne aged 19 to 45 years, meeting stringent inclusion criteria. Participants were randomized into three groups: one receiving elimination diets based on reversed IgG antibody measurements, another on common food-specific IgG antibodies, and a third on individual IgG antibody measurements. Elimination diets were informed by Genarrayt™ 200+ Food IgG kit results, with compliance monitored through dietary checklists. Primary outcomes were assessed using the Global Acne Grading System (GAGS) Score, with secondary outcomes including the Thai version of the Dermatology Life Quality Index Questionnaire and a Multiorgan-Symptoms Checklist. Follow-ups were conducted at 2, 4, 8, and 12 weeks. Results: The study cohort, predominantly female (74.7%), exhibited a mean age of 29.3 ± 5.3 years and an average GAGS Score indicating moderate acne severity. Significant differences in GAGS Scores were found among groups (P<0.001), indicating reduced acne severity in the elimination diet groups. Statistically significant reductions in weight and BMI were observed in one group (p-values = 0.048), but not in the other groups. Compliance with follow-up criteria was high. Conclusion: Elimination diets guided by food-specific IgG antibodies measurement show promise in reducing chronic adult acne severity, as indicated by GAGS Scores. This study sheds light on the relationship between diet and adult acne pathophysiology, emphasizing the potential of personalized treatment approaches. Further research is warranted to validate these findings and elucidate underlying mechanisms.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.006 | 0.006 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.003 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".