Stability of Diluted Desmopressin Acetate Intranasal Solution at 0.01 mg/mL.
Bibliographic record
Abstract
OBJECTIVE: In pediatrics, weight-based doses can be very small, leading to measuring tiny volumes of the commercial desmopressin nasal solution at 0.1mg/mL, which reduces precision and increases the risk of error. Since stability of the desmopressin acetate solution diluted at 0.01 mg/mL has not been properly demonstrated, the aim of this study was to demonstrate its 180 days physicochemical stability when stored in clear glass vials at 5°C and 25°C. Glass vials are used for their simplicity and user-friendliness. METHODS: The desmopressin acetate solutions were prepared by diluting a commercial nasal spray (0.1 mg/mL) with 0.9% sodium chloride to achieve a concentration of 0.01 mg/mL and aliquoted in clear glass vials. Stability study encompassed the samples being subjected to incubation at 5 ± 2°C and 25 ± 2°C/60 ± 5% RH for up to 180 days. Evaluation at specific intervals involved withdrawal of 1 mL aliquots for inspection of organoleptic properties and desmopressin acetate concentration assays using the HPLC-UV method. The particle count analysis was also performed on freshly prepared solutions at the initial time point and at the end of the study. The necessary microbiological tests were also carried out. RESULTS: The HPLC-UV method for desmopressin acetate quantification demonstrated robustness and low intraday variability (r2 = 0.999, highest RSD 0.40%). Stability studies over 180 days revealed no notable changes in odor and color, with consistent assay results and particle count evaluation meeting USP <788> criteria. No bacterial growth was noted. CONCLUSION: Desmopressin acetate prepared at 0.01 mg/mL from commercial nasal solutions using 0.9% sodium chloride when stored in clear glass vials at 5°C and 25°C remained stable for up to 180 days.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".