A Comparative Study of Bcl-2 Expression in Oral Leukoplakia with Dysplasia, Verrucous Carcinoma, and Oral Squamous Cell Carcinoma
Bibliographic record
Abstract
Aim: To study the immunohistochemical expression of Bcl-2 in oral leukoplakia with dysplasia, verrucous carcinoma and oral squamous cell carcinoma(OSCC). Methodology: A total of 80 formalin-fixed , paraffin- embedded specimens were selected , amongst them 30 cases of different grades of dysplasia- 10 mild, 10 moderate and 10 severe and 30 oral squamous cell carcinoma of various grades- 10 well differentiated, 10 moderately differentiated and 10 poorly differentiated, 10 verrucous carcinoma had been included in the study. 10 normal buccal mucosa were used as control group. Results: The immunohistochemical expression of Bcl-2 in oral leukoplakia with different grades of dysplasia, in verrucous carcinoma and in different grades of oral squamous cell carcinoma with normal mucosa were compared. Moreover, the expression of Bcl-2 was found to increase significantly between dysplasia and different grades of oral squamous cell carcinoma. Conclusion: The expression of Bcl-2 has always guided the researchers towards mapping the progression of dysplasia as well as malignant transformation at the molecular level.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".