Impact of Positive Airway Pressure on Right Ventricular Afterload in Pulmonary Arterial Hypertension
Bibliographic record
Abstract
Rationale: The impact of continuous positive airway pressure (CPAP) is currently unknown in patients with pulmonary arterial hypertension (PAH). The objective of the present study was to investigate the effect of CPAP on cardiopulmonary haemodynamics in patients with PAH compared to healthy volunteers. Methods: O. The primary outcome was the effect of CPAP on cardiopulmonary haemodynamics and intrapleural pressures within and between groups. Results: In both PAH (n=18) and healthy (n=5) participants the acute application of CPAP increased the oesophageal pressure significantly from baseline (all p<0.007). There was a decline in cardiac output in both groups from baseline (p=0.047), which was due to a reduction in heart rate (p=0.027) rather than stroke volume (p=0.8). CPAP significantly reduced right ventricular end-diastolic pressure (p=0.02), without a significant impact on resistive right ventricular afterload. CPAP did not significantly change pulmonary artery or pulmonary vascular resistance in either group. The calculated dynamic pulmonary arterial compliance was increased in both groups. Conclusions: In PAH and healthy participants, CPAP had a modest effect on intrapleural pressures. The transmural haemodynamic changes of CPAP were modest with a net increase in pulmonary vascular compliance in both groups, but no change in resistive right ventricular afterload in the PAH group. The current study did not demonstrate any deleterious effects of CPAP on pulmonary haemodynamics.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".