Effects of diesel exhaust inhalation on cognitive performance in human volunteers: A randomized controlled crossover study
Bibliographic record
Abstract
• Substantial evidence exists linking traffic-related air pollution (TRAP) to impairment in cognitive functioning. • We did first doubleblind crossover trial to investigate the effects of controlled TRAP on cognitive performance in humans. • Short-term exposure to diesel exhaust (DE) was associated with slower reaction times in the Reaction Time Index task. • DE exposure slowed reaction times similarly to those previously demonstrated with blood alcohol levels of 0.05%. • Implications exist for workers in occupations where attention and reaction time are connected to safety and performance. Mounting evidence links exposure to traffic-related air pollution (TRAP) to impairment in cognitive functioning. To determine if short-term, controlled exposure to diesel exhaust (DE) adversely affects one or more cognitive function domains. We carried out a double-blinded crossover design with 28 healthy, adult volunteers. Volunteers were exposed to two conditions for 120 min each, on separate order-randomized occasions: filtered air (FA) and DE (300 µg/m 3 PM 2.5 ) at the Air Pollution Exposure Laboratory (APEL) at Vancouver General Hospital (VGH). Volunteers were blinded to the two exposure conditions. Volunteers completed five computerised neuropsychological tests of the Cambridge Neuropsychological Test Automated Battery (CANTAB) prior to (2-hr before) and at three timepoints following each exposure condition (0-hr, 3-h post-, and 24-h post-exposure). The selected CANTAB tests were related to five cognitive domains – attention, spatial working memory, strategy use, executive function, and processing speed. We hypothesized that short-term diesel exposure would adversely affect one or more cognitive function domains. Following screening, 15 volunteers were randomized to receive FA followed by DE and 14 volunteers were randomized to receive the exposures in the reverse sequence. A total of 28 volunteers contributed to the final analysis. Short-term exposure to DE was associated with slower reaction times in the Reaction Time Index task. DE was associated with a decrease of 18.2 ms (p = 0.05) in simple reaction time and 23.5 ms (p = 0.04) in five-choice reaction time. This first study to investigate the effects of TRAP on the cognitive performance of humans in a controlled environment shows slowed reaction times similar to those previously demonstrated with blood alcohol levels of 0.05%. Important implications exist for workers in occupations where attention and reaction time are connected to safety and performance.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.004 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.005 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.002 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".