HIV-2 drug resistance genotyping and viral load among HIV-2 infected adults inBurkina Faso, West Africa
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
HIV-2 infection although less virulent compared to HIV-1 is endemic in many parts of West Africa. In Burkina Faso, few data exist on HIV-2 genotypic resistance. The objective of this study was to assess HIV-2 genotypic resistance and viral load in adult patients infected with HIV-2 in Burkina Faso. This was a cross-sectional study that ran from February 2017 to March 2019. This study included 91 HIV-infected adult patients on ARV treatment. HIV and hepatitis B and C status were confirmed by serological tests. HIV-2 viral load and HIV-2 clusters were determined by in-house tests. The mean age was 58.99 ±8.66 years. Of the patients, 12.1% were HIV-1, 73.6% were HIV-2 and 14.3% were co-infected with HIV-1/HIV-2. Only 15% had a high viral load (more than 1000 copies/mL). Groups A and B were detected in this study with the majority being group A (23.75%). HIV-2 subtype CRF01_AB was found in 3.75% of HIV-2 patients. Of the 34 HIV-2 patients whose subtypes were determined, only 7 had reverse transcriptase and 3 had protease resistance mutations. The M184V mutation was the most detected. This study revealed recent data on the status of HIV-2 genotypic resistance in Burkina Faso. Although few HIV-2 infected patients on ARV treatment have developed resistance, it is important to establish a surveillance system for HIV-2 genotypic resistance.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it