Elevated Activity in Left Homologous Music Circuits Is Inhibitory for Music Perception but Mediated by Structure–Function Coupling
Bibliographic record
Abstract
AIMS: Previous studies suggested that structural and functional connectivity of right frontotemporal circuits associate with music perception. Emerging evidences demonstrated that structure-function coupling is important for cognition and may allow for a more sensitive investigation of brain-behavior association, while we know little about the relationship between structure-function coupling and music perception. METHODS: We collected multimodal neuroimaging data from 106 participants and measured their music perception by Montreal Battery of Evaluation of Amusia (MBEA). Then we computed structure-function coupling, amplitude of low-frequency fluctuation (ALFF), gray matter volume (GMV), and structural/functional degree centrality (DC) and utilized support vector regression algorithm to build their relationship with MBEA score. RESULTS: We found structure-function coupling, rather than GMV, ALFF, or DC, contributed to predict MBEA score. Left middle frontal gyrus (L.MFG), bilateral inferior temporal gyrus, and right insula were the most predictive ROIs for MBEA score. Mediation analysis revealed structure-function coupling of L.MFG, a region that is homologous to typical music circuits, fully mediated the negative link between ALFF of L.MFG and MBEA score. CONCLUSION: Structure-function coupling is more effective when explaining variation in music perception. Our findings provide further understanding for the neural basis of music and have implications for cognitive causes of amusia.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".