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Record W4405856805

STUDY OF ORAL HEALTH AND SUPPORTIVE STRUCTURES FOR PROSTHETIC RESTORATIONS IN METHADONE MAINTENANCE THERAPY BENEFICIARIES AND DRUG USERS.

2024· article· en· W4405856805 on OpenAlexaff
G Dzodzuashvili, N. Chichua, V Margvelashvili, G Margishvili, N Dzodzuashvili

Bibliographic record

VenuePubMed · 2024
Typearticle
Languageen
FieldPharmacology, Toxicology and Pharmaceutics
TopicForensic Toxicology and Drug Analysis
Canadian institutionsCentre for Addiction and Mental Health
Fundersnot available
KeywordsMethadone maintenanceMethadoneMedicineDentistryDrugOral healthIntensive care medicinePsychiatry
DOInot available

Abstract

fetched live from OpenAlex

INTRODUCTION: Methadone Maintenance Therapy (MMT) is commonly used to treat opioid addiction but can cause significant oral health issues, including poor oral hygiene, dental caries, periodontal disease, and bone resorption. These issues can negatively impact on overall quality of life, leading to both aesthetic and functional concerns. AIM OF THE STUDY: This research compares the oral health of individuals in methadone maintenance treatment (MMT) with those starting MMT. It examines the correlation between methadone use, illicit drug use, and oral health, focusing on the condition of supportive structures for future prosthetic restorations. The study also explores how prosthodontic interventions can improve oral health. MATERIALS AND METHODS: This study was conducted at the Center for Mental Health and Prevention of Addiction in Tbilisi, Georgia, involving 276 patients (138 initiating Methadone Maintenance Therapy (MMT) for the first time and 138 MMT beneficiaries with at least six months of treatment). Stratified random sampling was used based on the duration of opioid addiction and length of MMT enrollment. A questionnaire was used to assess participants' dental health perceptions, oral hygiene habits, and experiences with prosthetic treatments. A dental chart was employed, including the Kennedy Classification, Prosthetic Diagnostic Index (PDI), Eichner Index, and Robert H. Griffiths' guidelines for temporomandibular disorder assessment. Additionally, the Oral Hygiene Index Simplified (OHI-S), DMFT index, Dental Health Index (DHI), and Periodontal Index were used to evaluate overall oral health and supportive structures for future prosthetic treatment. Data were analyzed using SPSS version 23, with statistical significance set at p<0.05. Participants provided informed consent in accordance with ethical guidelines. RESULTS: Group I (first-time MMT) showed higher caries experience (DMFT >13.9) compared to Group II (MMT beneficiaries), with 89.1% vs. 71.7%, respectively (p=0.001). Poor oral hygiene was observed more in Group I (24.6%) than Group II (17%) (p=0.000). The PDI revealed severely compromised edentulous areas in 32.6% of Group I and 39.1% of Group II (p=0.0492). Tooth mobility was more common in Group I (71.7%) vs. Group II (40.6%) (p=0.000). The remaining roots were found in 50% of Group I and 30.4% of Group II (p=0.001). Dry mouth complaints were higher in Group I (67.4%) vs. Group II (50.5%) (p=0.003). Significant edentulism and dissatisfaction with dentures were reported, especially in Group I. However, 54.3% of Group I felt their oral health stabilized with MMT (p=0.000). CONCLUSION: As a result, we can conclude that both groups have a high need for prosthetic rehabilitation. However, the condition of abutment teeth and periodontal tissues is not suitable, requiring adjunctive therapy. Methadone maintenance therapy (MMT) beneficiaries show slightly better conditions of these structures, but they also have a lower number of abutment teeth and significant bone resorption.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.009
Threshold uncertainty score0.017

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.118
GPT teacher head0.417
Teacher spread0.299 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations0
Published2024
Admission routes1
Has abstractyes

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