Predefined and data-driven CT radiomics predict recurrence-free and overall survival in patients with pulmonary metastases treated with stereotactic body radiotherapy
Bibliographic record
Abstract
BACKGROUND: This retrospective study explores two radiomics methods combined with other clinical variables for predicting recurrence free survival (RFS) and overall survival (OS) in patients with pulmonary metastases treated with stereotactic body radiotherapy (SBRT). METHODS: 111 patients with 163 metastases treated with SBRT were included with a median follow-up time of 927 days. First-order radiomic features were extracted using two methods: 2D CT texture analysis (CTTA) using TexRAD software, and a data-driven technique: functional principal components analysis (FPCA) using segmented tumoral and peri-tumoural 3D regions. RESULTS: Using both Kaplan-Meier analysis with its log-rank tests and multivariate Cox regression analysis, the best radiomic features of both methods were selected: CTTA-based "entropy" and the FPCA-based first mode of variation of tumoural CT density histogram: "F1." Predictive models combining radiomic variables and age showed a C-index of 0.62 95% with a CI of (0.57-0.67). "Clinical indication for SBRT" and "lung primary cancer origin" were strongly associated with RFS and improved the RFS C-index: 0.67 (0.62-0.72) when combined with the best radiomic features. The best multivariate Cox model for predicting OS combined CTTA-based features-skewness and kurtosis-with size and "lung primary cancer origin" with a C-index of 0.67 (0.61-0.74). CONCLUSION: In conclusion, concise predictive models including CT density-radiomics of metastases, age, clinical indication, and lung primary cancer origin can help identify those patients with probable earlier recurrence or death prior to SBRT treatment so that more aggressive treatment can be applied.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".