Effect of Metformin on Obesity, Hyperandrogenism and Insulin Resistance in Population with PCOS: A Clinical Analysis
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder in women, therapeutic methods include reducing obesity, hyperandrogenism and insulin resistance. This paper sorts out data from a clinical study that contains 83 Chinese PCOS patients in Control group, and 87 in Metformin group and analyzes the variation of parameters between baseline and after 4-month treatment. The Wilcoxon signed-rank test shows Metformin has a significant effect on obesity, hyperandrogenism and insulin resistance. They are measured by BMI, FAI and HOMA-IR respectively. The Spearman correlation analysis shows ΔFAI (variation after 4 months) is a mediator that is strongly correlated with ΔBMI and ΔHOMA-IR variation in PCOS patients. Linear regression concludes it as 10.64ΔBMI~ΔFAI~10.20ΔHOMA-IR. Metformin treatment has a stronger effect on decreasing HOMA-IR and BMI than FAI, as the relationship turns to 4.17ΔBMI~ΔFAI~5ΔHOMA-IR. This study fills the gap left by previous research which rarely focused on relationship of characteristic changes in PCOS patients, further explains Metformin treatment mechanism in evidence-based medicine perspective and provides strategy for new use of old medicine.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it