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Record W4406019252 · doi:10.1371/journal.pone.0310116

Unveiling chemical industry secrets: Insights gleaned from scientific literatures that examine internal chemical corporate documents—A scoping review

2025· article· en· W4406019252 on OpenAlexafffund
Blue Miaoran Dong, Marc‐André Gagnon

Bibliographic record

VenuePLoS ONE · 2025
Typearticle
Languageen
FieldPharmacology, Toxicology and Pharmaceutics
TopicPharmaceutical industry and healthcare
Canadian institutionsCarleton University
FundersSocial Sciences and Humanities Research CouncilSocial Sciences and Humanities Research Council of Canada
KeywordsSnowball samplingScientific literatureComputer scienceData scienceBusinessChemistryBiologyMathematicsStatistics

Abstract

fetched live from OpenAlex

OBJECTIVE: Examine peer-reviewed scientific articles that used internal industry documents in the chemical sector to reveal corporate influence. Summarize sources of internal documents used in prior scientific papers to identify ongoing corporate strategies within the chemical field. Compare the corporate strategies identified in the chemical sector with the ones identified already identified in the pharmaceutical sector. Propose a theoretical framework for categorizing and examining the different form of corporate capture at play. DESIGN: Performed a scoping review to pinpoint scientific papers employing internal industry/corporate documents within the chemical sector. METHODS: We conducted a systematic search using broad and case study-derived keywords, detailed in the S1 Appendix. This resulted in 351 sources from 28 databases, encompassing peer-reviewed articles analyzing internal documents of chemical corporations. We complemented our efforts with a snowball sampling method to uncover additional case studies and journal articles not initially captured by our search. Results were categorized and analyzed using Marc-Andre Gagnon and Sergio Sismondo's ghost management framework. RESULTS: The final results included and analyzed 18 scientific papers. Legal proceedings served as the primary source of internal document data for all examined articles. We uncovered and categorized dynamic strategies employed by chemical corporations to protect and advance their interests, including scientific capture (n = 16), regulatory capture (n = 15), professional capture (n = 7), civil society capture (n = 6), media capture (n = 4), legal capture (n = 4), technological capture (n = 3), and market capture (n = 2). COMPARATIVE ANALYSIS: The limited scientific literature meeting our criteria confirms early findings by Wieland et al, highlighting a research gap in the chemical industry. Our analysis, building on the ghost-management framework, shows a different emphasis in the way internal documents were used in scientific literature to understand corporate strategies at play in the chemical sector as compared to the pharmaceutical sector. In contrast to Gagnon and Dong's pharmaceutical corporate capture review, which identified 37 papers before 2022, our chemical industry findings reveal a lower count, with only 18 papers identified. Notably, the vast majority of the papers in both sectors shows an emphasis on analyzing strategies used for scientific capture. However, the area of regulatory capture reveals a significant distinction: only 6 of the 37 articles related to the pharmaceutical industry analyzed this dimension, as compared to 15 of the 18 articles related to the chemical industry. This body of work suggests that existing research on the chemical industry is particularly concerned with analyzing how the sector navigates and circumvents regulatory oversight. Both industries employ strategies involving conflicts of interest and the legitimization of their actions to shield themselves from public policy scrutiny and protect their interests. However, their goals seem to be significantly different. The scientific literature analyzing the pharmaceutical industry's internal document tends to identify strategies maximizing profits through the biased promotion of health products, whereas the scientific literature analyzing the chemical industry's internal documents is more inclined in identifying strategies institutionalizing ignorance about existing risks, evading accountability, and preventing regulatory actions. STRENGTHS: Our scoping review shows how internal documents can reveal how the chemical industry strategically institutionalizes ignorance to manage business risks. It exposes intentional efforts by chemical corporations to promote ignorance and foster conflicts of interest, thereby legitimizing their business models and safeguarding corporate interests. We shared our research findings on the Dataverse/ Borealis platform (https://doi.org/10.5683/SP3/EOIOAU), making them accessible for future studies to apply the same analytical framework seamlessly. LIMITATIONS: We excluded papers that did not meet our research criteria, prioritizing those that analyzed internal corporate documents for uncovering covert ghost management captures. Beyond scientific literature, various grey literature sources have conducted quality investigations on ghost management strategies in the chemical industry, and many leaked internal documents in the chemical industry, often available through toxicdocs.org, were not analyzed in the scientific literature. Also, market concentration and other corporate captures can be investigated using publicly available resources. Despite searching scientific papers in various languages, no relevant publications were found outside of English. This presents an opportunity for future research to conduct a separate scoping review.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.057
metaresearch head score (Gemma)0.223
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: Methods · Consensus signal: none
Study designCandidate signal: Systematic review · Consensus signal: Systematic review
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.943
Threshold uncertainty score0.302

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0570.223
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0030.003
Bibliometrics0.0910.066
Science and technology studies0.0030.005
Scholarly communication0.0120.013
Open science0.0030.006
Research integrity0.0040.002
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.515
GPT teacher head0.505
Teacher spread0.010 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designSystematic review
DomainMethods
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5
Published2025
Admission routes2
Has abstractyes

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Same venuePLoS ONESame topicPharmaceutical industry and healthcareFrench-language works237,207