Prospective analysis of clinical, cognitive and functional impairments among older adults following a diagnosis of covid
Bibliographic record
Abstract
BACKGROUND: Post-Covid syndrome has been associated to enduring impairments in functionality, cognition, mood and physical capabilities among older adults. METHODS: The objective was to prospectively evaluate clinical, cognitive and functional impairments in elderly people at 3 and 12 months after the diagnosis of Covid-19. Prospective cohort study of participants aged 60 years and over after a Covid-19 diagnosis. The project was approved by the UFMG's ethics committee. The assessment protocol included the scales Alzheimer's Disease Cooperative Study - Activities of Daily Living (ADCS-ADL), Canadian Occupational Performance Measure (COPM), Clinical Frailty Scale (CFS), Mattis Dementia Rating Scale (DRS), Post-Traumatic Stress Disorder Checklist - Civilian Version, Geriatric Depression Scale - 15 items, Charlson Comorbidity Index, modified Medical Research Council for dyspnea and Fatigue Severity Scale. The statistical analysis included Paired Samples T Test for continuous variables, the Mcnemar Test for categorical variables and the Sign Test for ordinal variables. RESULTS: Twenty-eight participants with a mean age of 69.46 ± 7.09 years and 8.04 ± 4.76 years of education were evaluated after 3 months (T1) and 12 months (T2). Women represented 56.6% and 82.1% of participants were hospitalized in the acute phase. There was an increase in frailty from 7.2% of frail people prior to covid diagnosis, to 39.3% at T1 (P = 0.004) and 32.2%, at T2 (p = 0.016) assessed by CFS. Functional recovery was not statistically significant (ADCS-ADL - P = 0.083), however, the subitem satisfaction and concerning functional performance assessed by COPM improved (P = 0.012). At (T1) 57.2% of the sample presented a diagnosis of MCI and 17.9% of dementia, while at (T2) 60.7% and 17.9%, respectively (P = 1.00). However, the DRS's conceptualization domain showed statistical significance improvement [P = 0.011]. Dyspnea symptoms had a significant improvement: from 82.2% with grade II to IV dyspnea at (T1) to 50% at T2 (P = 0.031). No changes were observed in fatigue, depressive symptoms and post-traumatic stress disorder. CONCLUSION: This study showed that symptoms such as fatigue, cognitive and functional changes may persist in older adults with following the diagnosis of covid. However, there was a significant improvement in dyspnea, in the DRS's conceptualization domain and satisfaction in relation to functional performance after 12 months of follow-up.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".