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Record W4406052280 · doi:10.1371/journal.pgph.0004039

Intergovernmental or fully independent? Designing a scientific panel on evidence for action against antimicrobial resistance

2025· article· en· W4406052280 on OpenAlexafffund
Arne Ruckert, Steven J. Hoffman, Susan Rogers Van Katwyk, Patrick Fafard, Mathieu J. P. Poirier

Bibliographic record

VenuePLOS Global Public Health · 2025
Typearticle
Languageen
FieldImmunology and Microbiology
TopicAntibiotic Use and Resistance
Canadian institutionsUniversity of OttawaCentre for Global Health ResearchYork University
FundersSocial Sciences and Humanities Research Council of CanadaWellcome Trust
KeywordsCorporate governanceContext (archaeology)DeclarationPolitical scienceScience policyFunction (biology)Scientific evidenceAction (physics)Public relationsEngineering ethicsPublic administrationEconomicsBiologyEngineeringEpistemologyLawManagement

Abstract

fetched live from OpenAlex

Effective global action against antimicrobial resistance (AMR) relies on the successful synthesis and translation of rigorous scientific evidence into policy and practice. Despite a call in 2019 by the Interagency Coordination Group on AMR to establish a policy-science interface, and the reaffirmation to establish a scientific panel in the 2024 Political Declaration on Antimicrobial Resistance, no authoritative entity currently exists that synthesizes the scientific evidence on AMR and outlines policy options based on the best scientific insight. A Scientific Panel on Evidence for Action against AMR (SPEA) could address this gap, as well as contribute to additional governance gaps in the space of AMR, by facilitating better global coordination and cooperation; establishing real-time evidence to guide policy actions; and monitoring progress towards any globally agreed upon AMR goals and targets. In this essay, we argue that SPEA has the potential to fulfill several governance functions, and we explore two design options for such a scientific panel to promote equitable and evidence-informed policy implementation. We first reflect on how the successes and failures of the Intergovernmental Panel on Climate Change (IPCC) should inform the SPEA. Building on these lessons, we then highlight the key functions of the SPEA, before proposing two models for how it could function in the context of the existing global governance of AMR. Finally, we reflect on the challenges inherent to each proposed governance model. The recent reaffirmation by the United Nations General Assembly to establish a scientific panel in the area of AMR represents a critical opportunity to enhance global AMR governance, promote evidence-based policy implementation, and foster international cooperation in combatting AMR.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.101
Threshold uncertainty score0.780

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.155
GPT teacher head0.355
Teacher spread0.200 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2025
Admission routes2
Has abstractyes

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