Bibliographic record
Abstract
Occupational asthma is defined as asthma that is caused by work exposures, accounting for approximately 10-15% of all new-onset adult asthma. Typically, this is a new-onset of asthma in workers with no previous history of asthma. However, the diagnosis may also be made in individuals who had previous childhood asthma that cleared, then recurred as an adult due to work exposure. In contrast, work-exacerbated asthma is defined as asthma that is exacerbated but not caused by work exposures. Occupational asthma can be caused by different mechanisms (Figure 1). It is most often due to a workplace sensitizer, which is a high- or low-molecular weight agent that causes asthma from an immunologic response. Asthma symptoms do not occur on the first exposure. Instead, they require a period ranging from days to years for sensitization. Once sensitized, subsequent exposures, even to very low levels of exposure, will trigger asthma. When this response is due to high-molecular weight sensitizers, which are typically proteins or glycoproteins, it is associated with specific IgE antibodies. In addition, specific IgE-antibodies are also associated with the response to some low molecular-weight sensitizers (chemical sensitizers) such as complex platinum salts and other metal salts. However, for most low-molecular weight sensitizers, the immune mechanism is unclear.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.002 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.027 | 0.008 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".