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Record W4406117390 · doi:10.47611/jsrhs.v12i4.5905

Biomarker Development for Endometriosis

2023· article· en· W4406117390 on OpenAlexaff
Rajagopal Appavu, Jothsna Kethar

Bibliographic record

VenueJournal of Student Research · 2023
Typearticle
Languageen
FieldMedicine
TopicEndometriosis Research and Treatment
Canadian institutionsCentennial College
Fundersnot available
KeywordsEndometriosisBiomarkerMedicineInternal medicineBiologyGenetics

Abstract

fetched live from OpenAlex

Endometriosis debilitates many women in the U.S. and around the world which is characterized by lesions either localized on the uterus or attached to other organs. These lesions act as endometrial tissue which means that during the monthly menstrual cycle, this tissue sheds which results in blood being stuck in body cavities. The only definitive way to diagnose endometriosis is to go through a laparoscopic procedure which is invasive and expensive. Patients may avoid their endometriosis and rely on pain medications to get relief from their symptoms. Biomarkers can be the next method of diagnosis which is noninvasive. Biomarkers can be taken from proteins during angiogenesis, blood, urine, saliva, and genomics. Blood and saliva have a common biomarker of miRNA. CA-125 in the blood is the most common biomarker used to detect endometriosis but it isn’t always accurate. Saliva can remain stable without extra precautions which makes it an ideal method of gaining and testing biomarkers. However, a panel of biomarkers may also be beneficial. Additionally, there may be specific genes in DNA that can show that a patient has endometriosis. An efficient, non-invasive diagnosis method is needed to reduce the amount of time taken to get a diagnosis and get treatment for symptoms closer to the onset of the disease.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.008
metaresearch head score (Gemma)0.015
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.009
Threshold uncertainty score0.041

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0080.015
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0030.002
Science and technology studies0.0010.001
Scholarly communication0.0040.002
Open science0.0010.002
Research integrity0.0020.003
Insufficient payload (model declined to judge)0.0090.004

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.379
GPT teacher head0.543
Teacher spread0.164 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

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