MétaCan
Menu
Back to cohort
Record W4406117390 · doi:10.47611/jsrhs.v12i4.5905

Biomarker Development for Endometriosis

2023· article· en· W4406117390 on OpenAlexaff
Rajagopal Appavu, Jothsna Kethar

Bibliographic record

VenueJournal of Student Research · 2023
Typearticle
Languageen
FieldMedicine
TopicEndometriosis Research and Treatment
Canadian institutionsCentennial College
Fundersnot available
KeywordsEndometriosisBiomarkerMedicineInternal medicineBiologyGenetics

Abstract

fetched live from OpenAlex

Endometriosis debilitates many women in the U.S. and around the world which is characterized by lesions either localized on the uterus or attached to other organs. These lesions act as endometrial tissue which means that during the monthly menstrual cycle, this tissue sheds which results in blood being stuck in body cavities. The only definitive way to diagnose endometriosis is to go through a laparoscopic procedure which is invasive and expensive. Patients may avoid their endometriosis and rely on pain medications to get relief from their symptoms. Biomarkers can be the next method of diagnosis which is noninvasive. Biomarkers can be taken from proteins during angiogenesis, blood, urine, saliva, and genomics. Blood and saliva have a common biomarker of miRNA. CA-125 in the blood is the most common biomarker used to detect endometriosis but it isn’t always accurate. Saliva can remain stable without extra precautions which makes it an ideal method of gaining and testing biomarkers. However, a panel of biomarkers may also be beneficial. Additionally, there may be specific genes in DNA that can show that a patient has endometriosis. An efficient, non-invasive diagnosis method is needed to reduce the amount of time taken to get a diagnosis and get treatment for symptoms closer to the onset of the disease.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.006
metaresearch head score (Gemma)0.009
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.559
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0060.009
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0040.003
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.379
GPT teacher head0.543
Teacher spread0.164 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

Explore more

Same venueJournal of Student ResearchSame topicEndometriosis Research and TreatmentFrench-language works237,207