Focused Ultrasound Lesioning of the Subthalamic Nucleus for Asymmetric Parkinson's Disease in Japan
Bibliographic record
Abstract
The data that support the findings of this study are available from the corresponding author upon reasonable request. Data S1. Supplementary Appendix Table S1. Demographic of subjects. Table presents the subjects’ baseline characteristics, with data expressed as median [interquartile range]. (minimum—maximum values). M, male; F, female; R, right; L, left; MDS-UPDRS, Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale. Table S2. Procedure details for focused ultrasound lesioning of subthalamic nucleus Initial target location, sonication dose and obtained temperature are shown in Table. Target locations are shown with positive values for lateral (L), anterior (A) and superior (S), and negative value for medial (M), posterior (P), and inferior (I). SDR, skull density ratio; MCP, midcommissural point; AC-PC, anterior commissure-posterior commissure; M, male; F, female; R, right; L, left. Table S3. Adverse events. Table shows the severity, course and outcome on all AEs. The severity of AEs was categorized into three grades: Mild (asymptomatic or mild symptoms), Moderate (minimal, local or non-invasive intervention indicated), Severe (disruption of activities of daily living). POD, postoperative day; MRI. Magnetic resonance imaging. Table S4. Details of dyskinesia and medication adjustment. Table details the clinical course of dyskinesia and medication adjustments. Dyskinesia subscores were calculated using the sum of MDS-UPDRS part IV item 4.1 and 4.2 (scores ranged from 0 to 8; higher scores indicate more severe symptom). POD, postoperative day; FUS, focused ultrasound, LED, levodopa equivalent dose; MDS-UPDRS, Movement Disorder Society-Unified Parkinson's Disease Rating Scale. Table S5. Changes in clinical and neuropsychiatric assessments. Table details clinical and neuropsychiatric assessments at each visit. All outcomes were shown as median [interquartile range]. NA, not available; MDS-UPDRS, Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale; MoCA-J, Japanese version of Montreal Cognitive Assessment; WMS-R, Wechsler Memory Scale—Revised; BDI, Beck Depression Inventory; NPI; JART, Japanese adult reading test. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.019 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".