A pilot study evaluating the feasibility, safety, and efficacy of transcranial photobiomodulation (tPBM) for the treatment of mild cognitive impairment (MCI): preliminary findings
Bibliographic record
Abstract
Abstract Background Mild Cognitive Impairment (MCI) is often a precursor to Alzheimer’s dementia (AD). Recent research underscores the relationship between mitochondrial dysfunction and amyloid‐beta accumulation, raising the prospect of targeting mitochondrial function for intervention. Transcranial photobiomodulation (tPBM), a non‐invasive technique utilizing near‐infrared light, has been shown to enhance mitochondrial function. Therefore, our study aimed to investigate the efficacy of tPBM in improving brain functions in MCI. Methods Fourteen (N = 14) participants with MCI recruited at St. Michael’s Hospital Memory Disorders Clinic were randomized (1:1) to either active or sham tPBM (Neuro RX Gamma, Vielight Inc). Participants underwent daily home‐based active or sham tPBM sessions over 6 weeks. Pre‐ and post‐treatment assessments included a comprehensive battery of tests, encompassing the Trail Making Test (TMT B & A), Mini‐Mental State Examination (MMSE), Proton Magnetic Resonance Spectroscopy (H‐MRS) of the posterior cingulate cortex, structural MRI, resting‐state functional MRI (rsfMRI), and blood‐based biomarker was collected using NMR spectroscopy quantitative and Neurology 3‐Plex A (N3PA) Assays. Results Comparing pre‐post changes in the active vs. sham group, we found significant differences favoring the active group (p’s<0.05) in: completing TMT‐B (t‐statistic = ‐2.1); for H‐MRS, decline in N‐acetyl aspartate to total creatine ratio (NAA/Cr) (t‐statistic = 2.8); increase in right thalamic volume (t‐statistic = 3.2); for rsfMRI, higher absolute change in functional connectivity in the default mode network (DMN) (t‐statistic = 3.5) and limbic network (t‐ statistic = 3.3), and between DMN and executive control network (ECN) (t‐statistic = 2.8); for blood results, decrease in isoleucine (t‐statistic = 3.0), methionine (t‐statistic = 3.1), and sarcosine (t‐statistic = 3.2) levels—markers linked to AD and amyloid plaque formation; and increase in butyrate (t‐statistic = ‐2.5) and L‐carnitine (t‐statistic = ‐2.6) levels—markers indicative of improved mitochondrial function. Furthermore, a notable trend was observed towards improved TMT B/A (p = 0.05, t‐statistic = ‐2.2) and MMSE (p = 0.06, t‐statistic = 2.0). Although the reduction in plasma tau levels within the active group was not statistically significant, it was notable (t‐statistic = 1.8). Conclusions Our pilot study suggests that tPBM could improve executive function, neuronal health, functional connectivity, and mitochondrial function, and decrease AD markers in patients with MCI. Further research with larger sample sizes is essential to replicate and validate these results.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".