Association of Longitudinal Change in Ambulatory Blood Pressure With Cognitive Decline in Older Adults
Bibliographic record
Abstract
Background: There has been no study about the association of longitudinal change in ambulatory blood pressure (BP) variability and level with cognitive decline. Objectives: The purpose of the study was to evaluate whether BP changes via ambulatory BP monitoring predict cognitive decline progression. Methods: Twice-annual ambulatory BP readings were examined during 5 years and their relationship with changes in the Japanese version of the Montreal Cognitive Assessment (MoCA-J) scores. BP variability was assessed using SD, coefficient of variation, and average real variability (ARV). Cognitive decline, defined as a change in the MoCA-J score, was assessed, with the threshold set at the quartile showing the greatest decrease, which we categorized as cognitive dysfunction (-4 points or less). Results: = 0.007), consistent across coefficient of variation and ARV. No association was found between changes in BP level and MoCA-J score decline. Conclusions: In older adults with controlled BP, increased BP variability was linked to cognitive decline, warranting further study as a prevention target.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".