Landscape of anti-IL-23 therapy in inflammatory bowel disease: recent advances
Bibliographic record
Abstract
Inflammatory bowel disease (IBD) commonly requires advanced therapies to induce and maintain durable remission. Interleukin (IL)-23 is a proinflammatory heterodimeric cytokine composed of a p40 subunit, which is shared with IL-12 and a unique p19 subunit. There are multiple streams of evidence that implicate IL-23 in the pathogenesis and pathophysiology of IBD and it has emerged as a crucial therapeutic target in IBD and several immune-mediated inflammatory diseases. Risankizumab, mirikizumab and guselkumab are monoclonal antibodies that selectively target the IL-23p19 subunit and offer a novel mechanism of action. This narrative review summarises key efficacy and safety data from the clinical trial programmes, highlights practical implications for their use in IBD, and reviews available data regarding their positioning in the rapidly expanding landscape of IBD treatments.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".