An injectable hydrogel for synergistic therapy in colorectal cancer by targeting glutathione
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Colorectal cancer (CRC) remains one of the leading causes of cancer-related deaths, with chemoresistance driven by elevated intratumoral glutathione (GSH) levels posing a major challenge for effective treatment. Here we report a multi-enzyme-like hydrogel (MELH), composed of thiolated carboxymethyl cellulose (CMC-SH), designed to deplete GSH and enhance the efficacy of 5-fluorouracil (5-FU). MELH modulates the tumor microenvironment through multi-functional roles, including glucose depletion and reactive oxygen species (ROS) generation. In cell-derived and patient-derived xenograft models, MELH significantly reduces tumor growth, increases apoptosis, and exhibits synergistic anti-tumor effects without notable toxicity. These findings demonstrate that MELH is an effective adjuvant therapy to overcome chemoresistance and improve treatment outcomes for advanced CRC.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it