High risk of drug-resistant tuberculosis in IGRA-negative contacts: should preventive treatment be considered?
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Abstract Purpose Deciding whether to provide preventive treatment to contacts of individuals with multidrug-resistant (MDR) tuberculosis is complex. Methods We present the diagnostic pathways, clinical course and outcome of tuberculosis treatment in eight siblings from a single family. Tuberculosis disease was diagnosed by Mycobacterium tuberculosis culture and molecular detection of M. tuberculosis-specific DNA from bronchopulmonary specimens using GeneXpert ® MTB/RIF. M. tuberculosis infection was diagnosed by an interferon-gamma release assay (IGRA; QuantiFERON ® -TB Gold Plus). Whole exome sequencing for genetic predisposition to mycobacterial infection was performed in one patient. Results Six of eight siblings aged 16–20 years from a migrant family of Somali origin were diagnosed with pulmonary MDR tuberculosis over a 12-month period. The remaining male siblings, aged 11 and 14 years, were asymptomatic during contact investigation. Chest radiographs, computed tomography (CT) scans, sputum cultures and nucleic acid amplification tests were negative, and the IGRA did not detect M. tuberculosis infection. A repeat CT scan eight months later was unremarkable, and repeated sputum cultures remained negative. In the absence of sufficient evidence of M. tuberculosis infection, no preventive treatment was offered. At month seven of consistent clinical observation, both children were diagnosed with pulmonary tuberculosis; the older with advanced disease and subsequent post-tuberculosis lung disease. Whole exome sequencing revealed no Mendelian variant associated with susceptibility to mycobacterial infection. Conclusion When significant risk of tuberculosis transmission exists, close contacts of MDR tuberculosis patients should be offered preventive treatment with levofloxacin despite a negative IGRA test result.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it