Disseminated blastomycosis with cutaneous involvement in a young man in Ottawa, Canada
Bibliographic record
Abstract
Dear Editor, Blastomycosis is a deep fungal infection caused by Blastomyces dermatitidis, typically starting in the lungs and potentially spreading to the skin.1 Diagnosis of skin lesions is challenging due to similarity to inflammatory and infectious dermatoses.2 A healthy 26-year-old man with a cough and pleuritic pain showed consolidation on X-ray and was initially treated for pneumonia. One month later, he developed crusted verrucous plaques (Figure 1a). Biopsy revealed fungal organisms in giant cells (Figure 1b), highlighted by silver staining (Figure 1c). He was treated with itraconazole for 6 months with follow-up. Early recognition and treatment are essential in preventing complications of blastomycosis. Clinical and histopathological findings in a patient with cutaneous blastomycosis. (a) Verrucous crusted plaques on the face show a cutaneous presentation of blastomycosis. (b) Haematoxylin and eosin staining shows pseudoepitheliomatous hyperplasia with mixed inflammatory infiltrates including multinucleated giant cells. The arrow points toward a fungal organism within the giant cell. (c) Silver staining highlights fungal organisms within histiocytes. This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors. No new data were generated or analysed in support of this research. Not applicable. Written patient consent for publication was obtained.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.003 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".