P0526 Association of plasma IgA with bowel wall thickness and disease activity in IBD patients assessed by intestinal ultrasound
Bibliographic record
Abstract
Abstract Background IgA, the primary immunoglobulin secreted by gut B cells, plays a key role in defending against pathogen invasion. Elevated plasma IgA levels have been observed in inflammatory bowel disease (IBD) patients, particularly those undergoing biologic therapy. However, direct evidence linking plasma IgA levels to bowel wall inflammation is lacking. This study investigates the relationship between plasma IgA levels and intestinal inflammation, using parameters from intestinal ultrasound (IUS). Methods We enrolled 30 IBD patients (20 with ulcerative colitis (UC) and 10 with Crohn’s disease (CD)) for IUS evaluation starting in July 2023. Ultrasound scores were based on the Milan ultrasound criteria (MUC) for UC and the bowel ultrasound score (BUSS) for CD. Plasma levels of ESR, CRP, albumin, IgA, partial Mayo score, and CDAI were collected at baseline, during treatment, and after 52 weeks of advanced therapy (Adalimumab, Vedolizumab, or Tofacitinib). IUS findings and plasma IgA levels were analyzed for correlations with clinical parameters using the Student’s t-test and linear regression. Results IUS findings were closely correlated with disease activity. In UC, the MUC score was positively correlated with CRP (P < 0.0001, R² = 0.4888), partial Mayo score (P = 0.0002, R² = 0.3652), and negatively with albumin levels (P = 0.0002, R² = 0.3747). In CD, the BUSS score showed a positive correlation with CDAI (P = 0.0394, R² = 0.2694). Plasma IgA levels were significantly associated with bowel wall thickness (BWT) in both UC and CD (P = 0.0041, R² = 0.1759) (Figure 1). Notably, when BWT exceeded 3.5 mm, plasma IgA levels increased significantly (P = 0.0021) (Figure 2). Interestingly, in CD, plasma IgA was strongly correlated with the BUSS score (P = 0.0001, R² = 0.6585), while no such relationship was observed between MUC score and plasma IgA in UC. Conclusion Plasma IgA levels are positively correlated with bowel wall thickness in both UC and CD patients, particularly when BWT exceeds 3.5 mm. In CD patients, IgA levels also show a strong correlation with the BUSS score, highlighting IgA as a potential biomarker for bowel wall inflammation. These findings suggest that plasma IgA could serve as a biomarker of disease activity, particularly in CD, and could aid in monitoring therapeutic response and disease progression in IBD. Further research is warranted to validate these results and explore the potential for IgA-targeted therapies. References 1.B Lee, J Hsu, T Tsai, A241 Correlation between plasma IgA level and biological therapy in inflammatory bowel disease, Journal of the Canadian Association of Gastroenterology, 2024;doi.org/10.1093/jcag/gwad061.241 Figure 1 Figure 2
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".