P0279 Assessing patient-reported health status in moderate-to-severe Crohn’s Disease and Ulcerative Colitis: Results from the communicating needs and features of IBD experiences (CONFIDE) survey
Bibliographic record
Abstract
Abstract Background Crohn’s disease (CD) and Ulcerative colitis (UC) affect patients’ physical and emotional well-being, posing substantial challenges to daily functioning.1 The CONFIDE study explored patients’ perspectives on the experiences and impact of CD and UC-related symptoms in the US, Europe (France, Germany, Italy, Spain, and UK), and Japan. Here, we assessed the impact of moderate-to-severe CD or UC on self-reported health status using the EQ-5D-5L questionnaire. Methods Online, quantitative, cross-sectional surveys were conducted among patients with moderate-to-severe CD or UC, defined by criteria based on previous treatment, steroid use, and/or hospitalisation. EQ-5D-5L assesses health status across 5 dimensions—mobility, self-care, usual activities, pain/discomfort, and anxiety/depression—rated from 1 (no problems) to 5 (extreme problems). It also includes a visual analogue scale (VAS) to rate current health from 0 (worst) to 100 (best).2 Descriptive statistics were used to summarise data. Results The analysis included 547 European (males [M]=55%, mean age=38 years [yrs]), 215 US (M=55%, 41 yrs), and 99 Japanese (M=68%, 43 yrs) patients with CD and 556 European (M=57%, 39 yrs), 200 US (M=62%, 40 yrs),and 124 Japanese (M=70%, 49 yrs) patients with UC. Of these, 347 (63%) European, 125 (58%) US, and 86 (87%) Japanese patients with CD, and 301 (54%) European, 153 (77%) US, and 52 (42%) Japanese patients with UC were receiving advanced therapies at data collection. Mean EQ-5D VAS scores were 67.9, 65.0, and 70.7 for European, US, and Japanese patients with CD, and 67.2, 67.0, and 73.1 for those with UC. Similar results were observed in patients receiving advanced therapies (Figure 1). Table 1 summarises health status across EQ-5D-5L dimensions. Of the 5 dimensions, most patients reported pain/discomfort and anxiety/depression. Overall, 81% European, 86% US, and 60% Japanese patients with CD reported ‘slight’ to ‘extreme’ pain/discomfort, while 74% European, 70% US, and 52% Japanese patients reported ‘slight’ to ‘extreme’ anxiety/depression. For UC, the percentages were 80% European, 91% US, and 39% Japanese patients for pain/discomfort, and 72% European, 80% US, and 40% Japanese patients for anxiety/depression. Conclusion Despite receiving advanced therapies, patients with CD or UC in Europe, US, and Japan reported impaired overall health by EQ-5D VAS scores. The European and US cohorts reported worse health, with a higher proportion of patients reporting problems across EQ-5D-5L dimensions than the Japanese cohort, possibly resulting from differences in characteristics of survey respondents, environment (e.g., bathroom access) and healthcare. References 1.Popov J, Farbod Y, Chauhan U, et al. Clin Exp Gastroenterol. 2021;14:123-131. 2.Mulhern B, O’Gorman H, Rotherham N, et al. Health Qual Life Outcomes. 2015;13:191.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.005 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".