P0434 Clinical patterns and prognosis according to the time of diagnosis in Korean IBD Patients with over 10 years of disease duration
Bibliographic record
Abstract
Abstract Background Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic condition marked by intestinal inflammation. IBD diagnosed in children tends to more extensive involvement, but generally responds well to treatment than adult-onset cases. This study aims to compare the long-term clinical characteristics, treatment patterns, and prognosis of IBD in patients diagnosed before and after age 18. Methods A retrospective study was conducted using data from 352 IBD patients with a disease duration exceeding 10 years across four hospitals. Baseline characteristics, disease status, and treatment patterns were analyzed at diagnosis, 5 years, 10 years, and currently. Results Of the 352 patients, 80 (22.7%) were diagnosed before the age of 18, and 272 (77.3%) were diagnosed at age 18 or older. Patients diagnosed before 18 years of age presented more frequently with CD (82.5% vs. 40.1%), while UC was predominant in those diagnosed later (17.5% vs. 59.9%). Younger patients had a significantly higher prevalence of abdominal pain (66.3% vs. 49.3%), malnutrition/weight loss (22.8% vs. 9.6%), and anal fistula/abscess (25.0% vs. 4.8%) at diagnosis. Younger patients had more pancolitis type in UC (50% vs. 31.9%), and more perianal disease in CD (53% vs 20.7%). Younger patients exhibited higher rates of steroid usage initially, with a gradual shift towards biologics such as infliximab. Over time, disease behavior in CD patients often progressed, especially among those diagnosed at age 18 or older. Multivariate analysis identified fever, fistula/abscess at diagnosis, and biologic use or discontinuation as significant risk factors for recurrence. Conclusion In patients diagnosed with IBD before the age of 18, Crohn’s disease (CD) is more common, often presenting with abdominal pain, perianal disease, and extensive involvement. However, with appropriate treatment can maintain remission and achieve better long-term outcomes. In conclusion, these findings suggest that age at IBD onset significantly impacts disease progression and treatment outcomes, underscoring the need for age-tailored management strategies in long-term IBD care. References 1.Thia KT, Loftus EV, Jr., Sandborn WJ, Yang SK (2008) An update on the epidemiology of inflammatory bowel disease in Asia. Am J Gastroenterol 103(12):3167-3182. 2.Duricova D, Burisch J, Jess T, et al. Age-related differences in presentation and course of pediatric inflammatory bowel disease; an update on the populationbased literature. J Crohns Colitis 2014;8(11):1351–61. 5. 3.Carroll MW, Kuenzig ME, Mack DR, et al. The impact of inflammatory bowel disease in Canada 2018: children and adolescents with IBD. J Can Assoc Gastroenterol 2019;2:S49–S67.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".