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Forever Chemicals PFAS Global Impact and Activities, Cascading Consequences of Colossal Systems Failure: Long-Term Health Effects, Food-Systems, Eco-Systems

2025· preprint· en· W4406744376 on OpenAlexaboutno aff
Jocelyn C. Lee, Slim Smaoui, John Duffill, Ben Marandi, Theodoros Varzakas

Bibliographic record

VenuePreprints.org · 2025
Typepreprint
Languageen
FieldEnvironmental Science
TopicChemical Analysis and Environmental Impact
Canadian institutionsnot available
Fundersnot available
KeywordsTerm (time)BusinessNatural resource economicsEnvironmental healthRisk analysis (engineering)Environmental scienceEconomicsMedicinePhysics

Abstract

fetched live from OpenAlex

Per- and polyfluoroalkyl substances (PFAS) are found everywhere including food, cosmetics, and pharmaceuticals. This review introduces PFAS comprehensively, discussing their nature, identifying the interconnection with microplastics, and their impacts on public health and the environment. The Human cost of decades of delay, cover-ups, and mismanagement of PFAS and plastic waste has been outlined and briefly explained. Following that PFAS and long-term health effects have been criti-cally assessed. Risk assessment has then been critically reviewed mentioning different tools and models. Scientific Research and Health Impacts in the United States of America have been critically analyzed tak-ing into consideration the Center for Disease Control (CDC) PFAS Medical Studies and Guidelines. PFAS impact, activities, and studies around the world have focused on PFAS Levels in Food Products and Dietary Intake in Different Countries such as China, European countries, USA and Australia. Moreover, PFAS in Drinking Water and Food have been outlined with regard to risks, mitigation, and reg-ulatory needs taking into account chemical contaminants in food and their Impact on health and safety. Finally, PFAS impact and activities briefings specific to regions around the world refer to Australia, Vi-etnam, Canada, Europe, and the United States of America. Crisis Multi-Faceted Issue, exacerbated by mismanagement has been discussed in the context of applying problem-solving analytical tools: the Domino Effect Model of accident causation, the Swiss Cheese Theory Model, and the Ishikawa Fish Bone Root Cause Analyses. Last but not least, the PFAS impact on the Sustainable Development Goals (SDGs) of 2030 has been rigorously discussed.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.017
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0020.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.002
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.048
GPT teacher head0.333
Teacher spread0.284 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2025
Admission routes1
Has abstractyes

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