Normal variations of myocardial T1, T2 and T2* values at 1.5 T cardiac MRI in sex-matched healthy volunteers
Why this work is in the frame
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Bibliographic record
Abstract
PURPOSE: The purpose of this study was to determine the normal variations of myocardial T1, T2, and T2* relaxation times on cardiac MRI obtained at 1.5 T in healthy, sex-balanced volunteers aged between 18 and 69 years. MATERIAL AND METHODS: A total of 172 healthy volunteers were recruited prospectively. They were further divided into seven sex-balanced age groups (18-19 years, 20-24 years, 25-29 years, 30-39 years, 40-49 years, 50-59 years, and 60-69 years). T1, T2, and T2* mapping were acquired in a single short-axis slice at the mid-level of the left ventricle. Global T1, T2, and T2* values were the mean of all segments. Comparisons between females and males were performed in each age group using independent samples t-test or Wilcoxon rank sum test, as appropriate. Multivariable linear effects models were used to analyze the effect of heart rate, body mass index, left ventricular mass, age, and sex on T1, T2, and T2* values. Inter- and intra-observer correlation (ICC) was evaluated. RESULTS: A total of 172 healthy participants were included. There were 83 males and 89 females, with a mean age of 37.3 ± 15.6 (standard deviation [SD]) years. Females had greater T1 values (980.9 ± 26.2 [SD] ms) compared to males (949.7 ± 18.3 [SD] ms) (P < 0.001). T1 values decreased with age (974.3 ± 26.97 [SD] ms when ≤ 39 years vs. 954.4 ± 24.12 [SD] ms when > 39 years; P < 0.001), with smaller sex-related differences in older participants. Male sex and age were independently associated with lower values of T1 mapping. Age in females was independently associated with lower T1, T2, and T2* values. Moderate to good inter- and intra-observer agreement was found for T1, T2, and T2* (ICC ranging from 0.72 to 0.89). CONCLUSION: T1, T2, and T2* values are influenced by age and sex, emphasizing the need to read and calibrate MRI values with respect to patient characteristics to avoid misdiagnosis.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it