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Record W4406855744 · doi:10.1073/pnas.2401238121

Automating the practice of science: Opportunities, challenges, and implications

2025· article· en· W4406855744 on OpenAlexaff
Sebastian Musslick, Laura Bartlett, Suyog Chandramouli, Marina Dubova, Fernand Gobet, Thomas L. Griffiths, Jessica Hullman, Ross D. King, J. Nathan Kutz, Christopher G. Lucas, Suhas Mahesh, Franco Pestilli, Sabina J. Sloman, William R. Holmes

Bibliographic record

VenueProceedings of the National Academy of Sciences · 2025
Typearticle
Languageen
FieldMaterials Science
TopicMachine Learning in Materials Science
Canadian institutionsUniversity of TorontoScience NorthUniversity of Alberta
FundersDivision of Information and Intelligent SystemsOffice of Advanced CyberinfrastructureEuropean Research CouncilNational Institute of Biomedical Imaging and BioengineeringUK Research and InnovationNOMIS StiftungEngineering and Physical Sciences Research CouncilFinnish Center for Artificial IntelligenceBrown UniversityKnut och Alice Wallenbergs StiftelseNational Science FoundationNokia FoundationNational Institutes of Health
KeywordsAutomationScope (computer science)Engineering ethicsFrontierDomain (mathematical analysis)Data scienceBest practiceComputer scienceKnowledge managementManagement scienceEngineeringPolitical science

Abstract

fetched live from OpenAlex

Automation transformed various aspects of our human civilization, revolutionizing industries and streamlining processes. In the domain of scientific inquiry, automated approaches emerged as powerful tools, holding promise for accelerating discovery, enhancing reproducibility, and overcoming the traditional impediments to scientific progress. This article evaluates the scope of automation within scientific practice and assesses recent approaches. Furthermore, it discusses different perspectives to the following questions: where do the greatest opportunities lie for automation in scientific practice?; What are the current bottlenecks of automating scientific practice?; and What are significant ethical and practical consequences of automating scientific practice? By discussing the motivations behind automated science, analyzing the hurdles encountered, and examining its implications, this article invites researchers, policymakers, and stakeholders to navigate the rapidly evolving frontier of automated scientific practice.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.098
metaresearch head score (Gemma)0.110
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: Methods · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Methods · Consensus signal: none
Teacher disagreement score0.902
Threshold uncertainty score0.520

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0980.110
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0040.005
Science and technology studies0.0130.062
Scholarly communication0.0270.031
Open science0.0040.015
Research integrity0.0100.010
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.071
GPT teacher head0.362
Teacher spread0.292 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designTheoretical or conceptual
DomainMethods
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations28
Published2025
Admission routes1
Has abstractyes

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Same venueProceedings of the National Academy of SciencesSame topicMachine Learning in Materials ScienceFrench-language works237,207