Contemporary pulmonary hypertension haemodynamic definitions stratify mortality risk in candidates for advanced heart failure therapies
Bibliographic record
Abstract
Extract Right heart catheterization (RHC) is performed to evaluate pulmonary hypertension (PH) in patients with Stage C-D chronic heart failure (HF) being considered for advanced therapies. However, the recommended thresholds of hemodynamic criteria at which to test PH reversibility (e.g., pulmonary artery systolic pressure (PASP) ≥50 mmHg) are relatively high, [1] considering that mean pulmonary artery pressure (mPAP) and pulmonary vascular resistance (PVR) are very low in healthy adults, [2, 3] and mortality increases with even mild PH. [4, 5] Contemporary guidelines have thus set the mPAP threshold for PH diagnosis at 20 mmHg, and reduced the PVR threshold indicating a pre-capillary component to 2 WU. [6–8] As a step toward incorporating current PH guidelines into advanced HF care, we grouped patients in our Canadian center by PH severity using specific criteria prompting reversibility testing and the broader hemodynamic definition. We then tested whether these PH groups were associated with 3-year mortality.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.006 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.003 | 0.003 |
| Insufficient payload (model declined to judge) | 0.004 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".