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Record W4407009455 · doi:10.1038/s41746-025-01457-w

Language models for data extraction and risk of bias assessment in complementary medicine

2025· article· en· W4407009455 on OpenAlexaff
Honghao Lai, Jiayi Liu, Chunyang Bai, Hui Liu, Bei Pan, Xufei Luo, Liangying Hou, Weilong Zhao, Danni Xia, Jinhui Tian, Yaolong Chen, Lu Zhang, Janne Estill, Jie Liu, Xing Liao, Nannan Shi, Xin Sun, Hongcai Shang, Zhaoxiang Bian, Kehu Yang, Luqi Huang, Long Ge, H. L. Li, Yu Wang, Huayu Zhang, Di Zhu, Dongrui Peng, Fan Wang, Yueyan Li, Shilin Tang, H.D. Liu, Zeming Li, Zhenhua Yang, Yu Xuan

Bibliographic record

Venuenpj Digital Medicine · 2025
Typearticle
Languageen
FieldMedicine
TopicComplementary and Alternative Medicine Studies
Canadian institutionsMcMaster UniversityImpact
FundersFundamental Research Funds for the Central UniversitiesChina Academy of Chinese Medical SciencesNational Natural Science Foundation of China
KeywordsComputer scienceData extractionExtraction (chemistry)Data scienceNatural language processingMEDLINEChemistryChromatography

Abstract

fetched live from OpenAlex

Large language models (LLMs) have the potential to enhance evidence synthesis efficiency and accuracy. This study assessed LLM-only and LLM-assisted methods in data extraction and risk of bias assessment for 107 trials on complementary medicine. Moonshot-v1-128k and Claude-3.5-sonnet achieved high accuracy (≥95%), with LLM-assisted methods performing better (≥97%). LLM-assisted methods significantly reduced processing time (14.7 and 5.9 min vs. 86.9 and 10.4 min for conventional methods). These findings highlight LLMs' potential when integrated with human expertise.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.398
metaresearch head score (Gemma)0.722
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesMetaresearch
DomainCandidate signal: Methods · Consensus signal: Methods
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.602
Threshold uncertainty score0.742

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.3980.722
Meta-epidemiology (narrow)0.0050.003
Meta-epidemiology (broad)0.0080.016
Bibliometrics0.0100.008
Science and technology studies0.0010.002
Scholarly communication0.0090.006
Open science0.0050.007
Research integrity0.0040.007
Insufficient payload (model declined to judge)0.0120.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.160
GPT teacher head0.454
Teacher spread0.294 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.

Study designSimulation or modeling
DomainMethods
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations35
Published2025
Admission routes1
Has abstractyes

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