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Record W4407132164 · doi:10.1002/aur.3312

Expanding Research on Contextual Factors in Autism Research: What Took Us So Long?

2025· article· en· W4407132164 on OpenAlexafffund
Marsha R. Mailick, Teresa Bennett, Leann Smith DaWalt, Maureen S. Durkin, Gordon Forbes, Patricia Howlin, Catherine Lord, Anat Zaidman‐Zait, Lonnie Zwaigenbaum, Vanessa H. Bal, Somer Bishop, Chung‐Hsin Chiang, Adriana Di Martino, Christine M. Freitag, Stelios Georgiades, Matthew J. Hollocks, Meng‐Chuan Lai, Matthew J. Maenner, Patrick Powell, Julie Lounds Taylor, Alycia Halladay

Bibliographic record

VenueAutism Research · 2025
Typearticle
Languageen
FieldNeuroscience
TopicAutism Spectrum Disorder Research
Canadian institutionsUniversity of TorontoCentre for Addiction and Mental HealthGlenrose Rehabilitation HospitalMcMaster Children's HospitalMcMaster UniversityUniversity of Alberta
FundersEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institute of Mental HealthNational Institute of Child Health and Human DevelopmentNational Institute for Health and Care ResearchNational Institutes of HealthStollery Children’s Hospital FoundationChildren's Hospital FoundationAutism Science FoundationPatient-Centered Outcomes Research Institute
KeywordsAutismPsychologyDevelopmental psychologyContext (archaeology)Psychological resilienceSocioeconomic statusAutism spectrum disorderCognitive psychologyPopulationSocial psychologySociology

Abstract

fetched live from OpenAlex

Although autism is a childhood-onset neurodevelopmental disorder, its features change across the life course due to a combination of individual and contextual influences. However, the influence of contextual factors on development during childhood and beyond is less frequently studied than individual factors such as genetic variants that increase autism risk, IQ, language, and autistic features. Potentially important contexts include the family environment and socioeconomic status, social networks, school, work, services, neighborhood characteristics, environmental events, and sociocultural factors. Here, we articulate the benefit of studying contextual factors, and we offer selected examples of published longitudinal autism studies that have focused on how individuals develop within context. Expanding the autism research agenda to include the broader context in which autism emerges and changes across the life course can enhance understanding of how contexts influence the heterogeneity of autism, support strengths and resilience, or amplify disabilities. We describe challenges and opportunities for future research on contextual influences and provide a list of digital resources that can be integrated into autism data sets. It is important to conceptualize contextual influences on autism development as main exposures, not only as descriptive variables or factors needing statistical control.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.028
metaresearch head score (Gemma)0.013
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow), Bibliometrics, Science and technology studies, Scholarly communication, Research integrity, Insufficient payload (model declined to judge)
Consensus categoriesScience and technology studies, Insufficient payload (model declined to judge)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.530
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0280.013
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0120.017
Science and technology studies0.0050.007
Scholarly communication0.0040.002
Open science0.0050.005
Research integrity0.0010.013
Insufficient payload (model declined to judge)0.0020.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.272
GPT teacher head0.488
Teacher spread0.215 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designTheoretical or conceptual
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations13
Published2025
Admission routes2
Has abstractyes

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