Neurovascular coupling over cortical brain areas and resting state network connectivity with and without rigidified carotid artery
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Bibliographic record
Abstract
Significance: Neurovascular coupling (NVC) is key to research as hemodynamics can reflect neuronal activation and is often used in studies regarding the resting state network (RSN). However, several circumstances, including diseases that reduce blood vessel elasticity, can diminish NVC. In these cases, hemodynamic proxies might not accurately reflect the neuronal RSN. Aim: We aim to investigate in resting state if (1) NVC differs over brain regions, (2) NVC remains intact with a mild rigidification of the carotid artery, (3) hemodynamic-based RSN reflects neuronal-based RSN, and (4) RSN differs with a mildly rigidified artery. Approach: ). With simultaneous GCaMP and intrinsic optical imaging, we compared neuronal activation to hemodynamic changes over the entire cortex. Results: NVC parameters did not differ between the CaCl and Sham groups. Likewise, GCaMP and hemodynamic RSN showed similar connections in both groups. However, the parameters of NVC differed over brain regions. Retrosplenial regions had a slower response and a higher HbR peak than sensory and visual regions, and the motor cortex showed less HbO influx than sensory and visual regions. Conclusions: NVC in a resting state differs over brain regions but is not altered by mild rigidification of the carotid artery.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it