A8 GREATER DISEASE BURDEN AMONG CANADIANS WITH CELIAC DISEASE MOST ECONOMICALLY DEPRIVED: FINDINGS FROM THE NATIONWIDE STATE OF CELIAC SURVEY
Bibliographic record
Abstract
Abstract Background Individuals with celiac disease (CeD) most economically deprived may face challenges adhering to the gluten-free diet (GFD). However, it is less clear how income may be associated with symptoms or comorbidity. Aims To determine symptom and comorbidity status across the economic spectrum among Canadians living with CeD. Methods At the end of 2022, the State of Celiac Disease in Canada Survey was administered to individuals living with CeD in Canada. Questions on GFD adherence, symptoms, and comorbidities were recorded by respondents. Participants who did not provide information on their household income (before tax) were excluded from analysis. The total number of symptoms and comorbidities were calculated per respondent, with symptoms further stratified into gastrointestinal (n=10), non-gastrointestinal (n=15), and neuropsychiatric (n=5). Tests of proportions and Kruskal-Wallis tests were used to assess for differences in outcomes across income levels. The Benjamini-Hochberg correction was used to account for multiple testing. Results A total of 3,950 respondents were included. Significant differences in gastrointestinal symptoms before and after diagnosis were detected across income groups (e.g., p<0.05 for those under $30,000 compared to all other income groups). Similar findings were present for non-gastrointestinal symptoms (e.g., p<0.01 for those under $30,000 compared to all other income groups except $30,000–49,999 before diagnosis) and neuropsychiatric symptoms (e.g., p<0.01 for those under $30,000 compared to all other income groups). The number of comorbidities also differed significantly across certain income levels (e.g., p<0.01 for those under $30,000 compared to all other income groups). There were no differences in accidental gluten consumption across income categories, although a borderline significant difference (p=0.06) was observed for intentional gluten consumption between those with income under $30,000 compared to those with income greater than $150,000. Conclusions There are notable differences in CeD across an economic gradient, with those in lower income brackets living with a greater number of symptoms and comorbidities. Further attention is warranted to minimize additional burden from CeD among individuals with limited income. Comorbidity status and gluten consumption across income levels Symptoms experienced before and after diagnosis across income level Funding Agencies Celiac Canada
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.002 | 0.005 |
| Science and technology studies | 0.003 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".