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Record W4407302009 · doi:10.1101/2025.02.07.25321887

SARS-CoV-2 Aggregated Activity Level Across Ontario Canada, Measured with the US CDC Wastewater Viral Activity Level (WVAL) Metric

2025· preprint· en· W4407302009 on OpenAlexafffundabout
Robert Delatolla, Christopher T. DeGroot, R. Michael L. McKay, Mark R. Servos, Steven McAvoy, S. Krishnakumar, Orchid Jo, Michael Fung, Sherif Hegazy, Tim D. Fletcher, Albert Simhon, Vince Pileggi

Bibliographic record

VenuemedRxiv · 2025
Typepreprint
Languageen
FieldMedicine
TopicSARS-CoV-2 detection and testing
Canadian institutionsMinistry of the Environment, Conservation and ParksUniversity of WaterlooUniversity of WindsorWestern UniversityUniversity of Ottawa
FundersCenters for Disease Control and PreventionMinistère de l’Environnement, de la Protection de la nature et des Parcs
KeywordsCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Metric (unit)2019-20 coronavirus outbreakWastewaterPhysical activityEnvironmental scienceVirologyBusinessMedicineEnvironmental engineeringMarketing

Abstract

fetched live from OpenAlex

Abstract The wastewater viral activity level (WVAL) was developed by the United States Centers for Disease Control and Prevention (US CDC) as a standardized metric to aggregate SARS-CoV-2 wastewater data, enabling the assessment of infection levels and trends at state/territorial, regional and national scales. This approach also facilitates comparative analysis of SARS-CoV-2 prevalence across regions. In this study, we developed and evaluated graphical methods to integrate the WVAL metric into interpretable visualizations for public health decision-making. Preliminary analysis demonstrated that WVAL values correlated strongly with clinical case counts, supporting its role as a confirmatory epidemiological measure. The WVAL framework provided a linear quantification method, allowing for the comparison of regional variations in infection patterns. This study leveraged data from the Ontario Wastewater Surveillance Initiative (Ontario WSI), which included over 100 sampling sites across seven geographical regions. Weekly mean WVAL values were computed for each site and aggregated at regional and provincial levels. In total, 59 sites contributed to the provincial WVAL calculation. The computational aggregation method followed the US CDC’s WVAL approach and was generally comparable to the Public Health Ontario (PHO) aggregation method, with the notable improvement of incorporating a linear level scale. Overall, this study demonstrated that WVAL effectively quantified SARS-CoV-2 differences at a public health regional scale. The WVAL metric proved to be a robust epidemiological tool, complementing other surveillance measures to support public health decision-making.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Research integrity
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.173
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0010.004
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.097
GPT teacher head0.309
Teacher spread0.212 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes3
Has abstractyes

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