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Record W4407653444 · doi:10.3892/mmr.2025.13461

[Retracted] Upregulation of Stat1‑HDAC4 confers resistance to etoposide through enhanced multidrug resistance 1 expression in human A549 lung cancer cells

2025· article· en· W4407653444 on OpenAlexaff
Chutima Kaewpiboon, Ratakorn Srisuttee, Waraporn Malilas, Jeong Moon, Sangtaek Oh, Hye Gwang Jeong, Randal N. Johnston, Wanchai Assavalapsakul, Young-Hwa Chung

Post-publication record

OpenAlex flags this work as retracted, but it carries no matching Retraction Watch record in this frame.

Bibliographic record

VenueMolecular Medicine Reports · 2025
Typearticle
Languageen
FieldMedicine
TopicPeptidase Inhibition and Analysis
Canadian institutionsUniversity of Calgary
Fundersnot available
KeywordsResistance (ecology)Multiple drug resistanceMolecular biologyChemistryCancer researchBiologyGeneticsDrug resistance

Abstract

fetched live from OpenAlex

Following the publication of this article, an interested reader drew to the Editor’s attention that a pair of data panels in the cellular images shown in Fig. 1A on p. 2317 appeared to be overlapping, such that data which were intended to show the results from differently performed experiments had appparently been derived from the same original source. Moreover, in Fig. 1C and 5A, there appeared to be discrete splicing events for gel slices featured in these figure parts, and for the immunoblotting experiments shown in Fig. 2B, striking likenesses of certain of the bands appeared in different positions in different gels relative to each other where different experimental conditions were being shown, which seemed difficult to attribute purely to coincidence. After having conducted an internal investigation, the Editor of Molecular Medicine Reports agrees with the reader that there were anomalies associated with the presentation of Figs. 1, 2 and 5. Therefore, on the grounds of a lack of confidence in the presented data, the Editor has decided that the article should be retracted from the publication. Upon contacting the authors, all the authors agreed with the decision to retract this paper, except for Dr Randal Johnston, who was not contactable owing to his retirement several years ago. The Editor apologizes to the readership for any inconvenience caused, and we also thank the reader for bringing this matter to our attention. [Molecular Medicine Reports 11: 2315‑2321, 2015; DOI: 10.3892/mmr.2014.2949]

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.005
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.024
Threshold uncertainty score0.082

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.005
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.002
Science and technology studies0.0010.002
Scholarly communication0.0030.002
Open science0.0040.001
Research integrity0.0040.005
Insufficient payload (model declined to judge)0.0240.014

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.329
Teacher spread0.322 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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