MétaCan
Menu
Back to cohort
Record W4407677183 · doi:10.1097/dss.0000000000004569

A Randomized Controlled Trial Evaluating Traditional Versus Extended Techniques of Poly-l-Lactic Acid Injection for the Aesthetic Improvement of the Temporal Fossae

2025· article· en· W4407677183 on OpenAlexaff
Andreas Nikolis, Frank Rosengaus, Tyler Safran, Kaitlyn M. Enright

Bibliographic record

VenueDermatologic Surgery · 2025
Typearticle
Languageen
FieldMedicine
TopicFacial Rejuvenation and Surgery Techniques
Canadian institutionsMcGill University Health CentreMcGill University
Fundersnot available
KeywordsMedicineRandomized controlled trialAdverse effectPatient satisfactionVisual analogue scaleLactic acidSurgeryInternal medicine

Abstract

fetched live from OpenAlex

BACKGROUND: Poly- l -lactic acid (PLLA-SCA) can be used to improve the aesthetics of the temporal fossae but is usually only deposited within the visible area of the temporal hollows. However, extending the treatment area posterior to the hairline may provide a greater lifting effect. OBJECTIVES: Assess the efficacy and safety of 2 techniques (traditional vs extended) of injecting PLLA-SCA for aesthetic improvement of the temporal fossae. MATERIALS AND METHODS: A prospective, randomized-controlled clinical trial was conducted. Twenty-four subjects were randomized in a 1-to-1 ratio to the traditional or extended injection technique. Subjects received 3 treatments (Baseline, Week 7, Week 14) and were evaluated for follow-up at Weeks 20, 26, and 38. Assessments included the Global Aesthetic Improvement Scale (GAIS), Temple Volume Deficit Scale (TVDS), lifting and volumizing effects, subject satisfaction, and adverse events. RESULTS: A greater facial lifting effect ( p < .001) and mean decrease in TVDS scores were observed with the extended injection technique. Regardless of injection technique, all subjects were at least improved on the GAIS at Week 38, and there was a low frequency of adverse events. CONCLUSION: Poly- l -lactic acid is a safe and effective treatment for improving the aesthetic appearance of the temporal fossae. Outcomes can be maximized using an extended injection technique.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.007
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.099
Threshold uncertainty score0.780

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0040.007
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.072
GPT teacher head0.351
Teacher spread0.279 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5
Published2025
Admission routes1
Has abstractyes

Explore more

Same venueDermatologic SurgerySame topicFacial Rejuvenation and Surgery TechniquesFrench-language works237,207